帕金森病抑郁症神经网络机制的多模态脑影像研究

项目名称： 帕金森病抑郁症神经网络机制的多模态脑影像研究

项目编号： No.81471646

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 谭长连

作者单位： 中南大学

项目金额： 70万元

中文摘要： 帕金森病（PD）为老年人最常见的神经退行性疾病之一，高达40%-50%的PD患者伴发抑郁，被称为帕金森病抑郁症（dPD），dPD的临床表现及神经机制不同于单纯的抑郁症，可能是一种特殊的器质性抑郁，但具体神经机制不明。本研究采用磁共振成像技术与药物干预相结合的方法，以药物作用机制作为切入点，以不伴抑郁的PD患者及单纯抑郁症作对照，追踪dPD患者在不同类型药物治疗前后的脑结构与脑功能影像变化，通过对多模态脑影像检测结果进行全面的比较分析，构建脑神经网络模型，从以下几方面探讨dPD的神经病理机制：（1）dPD患者是否存在不同于单纯PD及单纯抑郁的特征性神经网络模型；（2）dPD是否有特征性神经网络的病理性标志；（3）不同类型抗抑郁药对dPD患者神经网络的效应差异。该研究将为dPD的早期识别与诊断提供脑影像指标，为PD的分类诊断及个体化治疗提供新的思路和科学依据。

中文关键词： 帕金森病；抑郁症；脑网络；磁共振成像

英文摘要： Parkinson's disease (PD) is one of the most common neurodegenerative diseases in the elderly, and as high as 40% - 50% of PD patients are in depression, which was named depression in PD (dPD). Results of research suggest that both depressive symptoms and underlying neurobiological mechanisms of dPD might be different from those of the depressive disorder without PD. It could be assumed that dPD be a special organic depression, however, the specific neural mechanism of dPD remains unclear. With magnetic resonance imaging (MRI) and drug intervention combined, PD patients without depression or patients with pure depression as control group, this project will follow up the brain structure and brain function imaging changes of dPD patients, who will accept different types of antidepressants, before and after the treatment. Based on multimodal and comprehensive brain imaging data analysis, neural network models would be constructed, and the neural pathological mechanism for dPD would be explored by: (1) whether the neural network model of dPD patients is different from those of patients with PD without depression and patients with pure depression; (2) what is the characteristic pathologic signs of neural network for dPD; (3) what are the different effects of antidepressants on the neural network in patients with dPD. This project will provide brain image index for early recognition and diagnosis of dPD, and offer new and scientific evidences for the diagnosis classification and individualized treatment of PD.

英文关键词： Parkinson's disease;depression;neural network;MRI