首发抑郁症情绪与认知交互作用机制脑电研究

项目名称： 首发抑郁症情绪与认知交互作用机制脑电研究

项目编号： No.60871090

项目类型： 面上项目

立项/批准年度： 2009

项目学科： 无线电电子学、电信技术

项目作者： 李颖洁

作者单位： 上海大学

项目金额： 30万元

中文摘要： 抑郁症是最常见的精神障碍，以显著而持久的情绪低落为主要临床特征，发病机制不明。近年的研究表明患者也存在明显的认知执行功能偏差，但是关于抑郁症的特异性认知损伤类型及脑功能障碍定位仍存在较大争议。主要原因是这些研究没有进一步探讨认知执行功能与情绪信息加工之间的交互作用。本课题在设计神经电生理实验的基础上，将事件相关脑电动力学分析、信息学引入到抑郁症情绪认知加工研究中。主要研究内容包括：(1)设计不同认知任务难度的情绪刺激下的神经电生理实验；课题从三种不同的实验方案展开了不同研究对象(2)分析正/负/中情绪刺激下研究对象认知过程的脑电动力学特性，侧重非线性特性；(3)研究记录认知加工过程信息导向的方法，侧重信息传递有向性。课题旨在研究情绪障碍与认知功能损害间的相互联系，描绘情绪认知加工过程中的电生理信息传递拓朴图，阐明抑郁症的神经生理学发病机制。研究成果可望应用于情绪研究、抑郁症早期诊断、复发预测和康复评估等重要理论和实际临床问题。

中文关键词： 抑郁症；事件相关脑电；情绪与认知交互

英文摘要： Depression is one of the most common mental disorders, who is characterized by persistent negative moods. However，the mechanism of depression remains unclear. Apparent cognitive and executive deficits in depressed patients have been reported. While the interaction of cognition and emotion has been ignored in the present investigations,which limits the further progress in psychology of depression, especially in the specified patterns of cognitive deficits and localization of the brain dysfunction. In this study, on the basis of the neuro-electrophysiological experiments, the interaction of cognition and emotion will be investigated, combining dynamic analysis and information theory on event-related EEG signals. The main body consists of three parts: (1) Design neuro-electrophysiological experiments with variable difficulty tasks in response to different emotional stimuli; (2) Dynamic analysis of individual cognitive processing in response to positive/neutral/negative emotions, focusing on their non-linear characterizations; (3) Develop methodology of information transfer during the cognitive processing, reflecting the directions of the information transfer. The study aims to explore the relationship of mental disorders and cognitive deficits, depict the topographic patterns of electrophysiological information transfer during emotional /cognitive processing and provide more mechanical evidence for depression. It will help both the basic and clinical researches including the study of emotion, the early diagnosis of depression, and the prediction of the recurrence and the estimation of remission.

英文关键词： depression; event-related EEG; interaction between emotion and cognition