Self-supervised based general laboratory progress pretrained model for cardiovascular event detection

Regular surveillance is an indispensable aspect of managing cardiovascular disorders. Patient recruitment for rare or specific diseases is often limited due to their small patient size and episodic observations, whereas prevalent cases accumulate longitudinal data easily due to regular follow-ups. These data, however, are notorious for their irregularity, temporality, sparsity, and absenteeism. In this study, we leveraged self-supervised learning (SSL) and transfer learning to overcome the above-mentioned barriers, transferring patient progress trends in cardiovascular laboratory parameters from prevalent cases to rare or specific cardiovascular events detection. We pretrained a general laboratory progress (GLP) pretrain model using hypertension patients (who were yet to be diabetic), and transferred their laboratory progress trend to assist in detecting target vessel revascularization (TVR) in percutaneous coronary intervention patients. GLP adopted a two-stage training process that utilized interpolated data, enhancing the performance of SSL. After pretraining GLP, we fine-tuned it for TVR prediction. The proposed two-stage training process outperformed SSL. Upon processing by GLP, the classification demonstrated a marked improvement, increasing from 0.63 to 0.90 in averaged accuracy. All metrics were significantly superior (p < 0.01) to the performance of prior GLP processing. The representation displayed distinct separability independent of algorithmic mechanisms, and diverse data distribution trend. Our approach effectively transferred the progression trends of cardiovascular laboratory parameters from prevalent cases to small-numbered cases, thereby demonstrating its efficacy in aiding the risk assessment of cardiovascular events without limiting to episodic observation. The potential for extending this approach to other laboratory tests and diseases is promising.