From a quarter million people sampled 2004 from AOK health claims and followed until 2013, we investigate the effect of having a stroke on the probability of dementia onset for Germans born in the first half of the 20$^{th}$ century. People deceased before 2004 are randomly left-truncated. Filtrations, modelling the missing data, enable to circumvent the unknown number of truncated persons by using a conditional instead of the full likelihood. Dementia onset after 2013 is a conditionally fixed right-censoring event. For each observed health history, including eventually the two diseases and inevitably death, Jacod's formula yields the conditional likelihood contribution. Asymptotic normality of the estimated intensities is derived, relative to a sample size definition that includes the truncated people. Yet, the standard error is observable. The claims data reveal that after a stroke, with time measured in years, the intensity of dementia onset increases from 0.02 to 0.07. Using the independence of the two estimated intensities, a $95\%$-confidence interval for their difference is $[0.048,0.051]$. The width halves, when we extend the analysis to an age-inhomogeneous model.
翻译:从2004年从AOK健康索赔中抽样调查的25万人中,从2004年的25万人从AOK健康索赔中抽取,直到2013年为止,我们调查了中风对德国人在20美元世纪前半叶出生的痴呆发作概率的影响。2004年以前死亡的人随机左转,对2004年以前的人进行随机左转。通过使用有条件而非完全可能性的分类,模拟缺失的数据,能够绕过未知的缺勤人数。2013年之后的痴呆症发作是一个有条件的固定右检查事件。对于观察到的每一个健康历史,包括最终两种疾病和不可避免的死亡,Jacod的公式产生有条件的概率贡献。估计强度的正常性是相对于包括被疏漏的人的抽样规模定义得出的。但标准错误是可以观察的。索赔数据显示,经过一次中风之后,经年测量的时间,痴呆开始的强度从0.02年增加到0.07年。利用两种估计的强度的独立性,其差异的我们950-50美元的安全度间隔时间是模型。