The role of epidemiological models is crucial for informing public health officials during a public health emergency, such as the COVID-19 pandemic. However, traditional epidemiological models fail to capture the time-varying effects of mitigation strategies and do not account for under-reporting of active cases, thus introducing bias in the estimation of model parameters. To overcome these modelling challenges, we extend the SIR and SEIR epidemiological models with two time-varying parameters that capture the transmission rate and the rate at which active cases are reported to health officials. Using two real datasets of COVID-19 cases, we perform Bayesian inference via our SIR and SEIR models with time-varying transmission and reporting rates and via their standard counterparts with constant rates. Our approach provides parameter estimates with more realistic interpretation, and one-week ahead predictions with reduced uncertainty.
翻译:流行病学模型的作用对于在公共卫生紧急情况(如COVID-19大流行)期间向公共卫生官员通报公共卫生官员至关重要,然而,传统的流行病学模型未能捕捉减缓战略的时间变化效应,也没有说明未充分报告积极病例的情况,从而在模型参数估计方面造成偏差。为克服这些模型挑战,我们将SIR和SEIR流行病学模型扩展为两个时间变化参数,其中反映传染率和向卫生官员报告积极病例的速度。我们使用COVID-19两套真实数据集,通过SIR和SEIR模型,用时间变化的传播和报告率,并通过标准对应单位,以不变的比率,进行巴伊西亚推论。我们的方法为参数估算提供更现实的解释,并提前一周预测不确定性减少。