We present a novel and easy to use method for calibrating error-rate based confidence intervals to evidence-based support intervals. Support intervals are obtained from inverting Bayes factors based on the point estimate and standard error of a parameter estimate. A $k$ support interval can be interpreted as "the interval contains parameter values under which the observed data are at least $k$ times more likely than under a specified alternative hypothesis". Support intervals depend on the specification of a prior distribution for the parameter under the alternative, and we present several types that allow data analysts to encode different forms of external knowledge. We also show how prior specification can to some extent be avoided by considering a class of prior distributions and then computing so-called minimum support intervals which, for a given class of priors, have a one-to-one mapping with confidence intervals. We also illustrate how the sample size of a future study can be determined based on the concept of support. Finally, we show how the universal bound for the type-I error rate of Bayes factors leads to a bound for the coverage of support intervals, holding even under sequential analyses with optional stopping. An application to data from a clinical trial illustrates how support intervals can lead to inferences that are both intuitive and informative.
翻译:我们提出了一个新颖的、容易使用的方法,用于校准基于错误的信任间隔,以证据为基础的支持间隔。根据点估计和参数估计的标准误差,从倒置贝ys系数中获得了支持间隔。一个美元支持间隔可以被解释为“间隔包含参数值,根据参数值,观测到的数据至少比特定替代假设的概率高出1倍。”支持间隔取决于替代参数先前分配的规格,我们提出几种类型,使数据分析员能够对不同形式的外部知识进行编码。我们还表明,通过考虑一个先前的分发类别,然后计算所谓的最低限度支持间隔,在某种程度上可以避免事先的规格。对于某类前期,这种间隔具有一对一的测量,带有信任间隔。我们还说明了如何根据支持概念确定未来研究的样本大小。最后,我们展示了对贝ys系数类型一的通用约束率如何导致支持间隔的束缚,甚至根据连续分析进行,并有选择停止。临床试验中的数据应用了一种支持间隔,从而可以推导出信息间隔。