We propose and justify a matrix reduction method for calculating the optimal approximation of an observed matrix $A \in {\mathbb C}^{m \times n}$ by a sum $\sum_{i=1}^p \sum_{j=1}^q B_iX_{ij}C_j$ of matrix products where each $B_i \in {\mathbb C}^{m \times g_i}$ and $C_j \in {\mathbb C}^{h_j \times n}$ is known and where the unknown matrix kernels $X_{ij}$ are determined by minimizing the Frobenius norm of the error. The sum can be represented as a bounded linear mapping $BXC$ with unknown kernel $X$ from a prescribed subspace ${\mathcal T} \subseteq {\mathbb C}^n$ onto a prescribed subspace ${\mathcal S} \subseteq {\mathbb C}^m$ defined respectively by the collective domains and ranges of the given matrices $C_1,\ldots,C_q$ and $B_1,\ldots,B_p$. We show that the optimal kernel is $X = B^{\dag}AC^{\dag}$ and that the optimal approximation $BB^{\dag}AC^{\dag}C$ is the projection of the observed mapping $A$ onto a mapping from ${\mathcal T}$ to ${\mathcal S}$. If $A$ is large $B$ and $C$ may also be large and direct calculation of $B^{\dag}$ and $C^{\dag}$ becomes unwieldy and inefficient. { The proposed method avoids} this difficulty by reducing the solution process to finding the pseudo-inverses of a collection of much smaller matrices. This significantly reduces the computational burden.
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