We present a novel and easy-to-use method for calibrating error-rate based confidence intervals to evidence-based support intervals. Support intervals are obtained from inverting Bayes factors based on a parameter estimate and its standard error. A $k$ support interval can be interpreted as "the observed data are at least $k$ times more likely under the included parameter values than under a specified alternative". Support intervals depend on the specification of prior distributions for the parameter under the alternative, and we present several types that allow different forms of external knowledge to be encoded. We also show how prior specification can to some extent be avoided by considering a class of prior distributions and then computing so-called minimum support intervals which, for a given class of priors, have a one-to-one mapping with confidence intervals. We also illustrate how the sample size of a future study can be determined based on the concept of support. Finally, we show how the bound for the type-I error rate of Bayes factors leads to a bound for the coverage of support intervals. An application to data from a clinical trial illustrates how support intervals can lead to inferences that are both intuitive and informative.
翻译:我们提出了一个用于校准错误率基础信任间隔的新颖和易于使用的方法,以证据为基础的支持间隔。根据参数估计及其标准差错,从倒置贝ys系数中获得了支持间隔。一个 $k$的支持间隔可以被解释为“观察到的数据在包含参数值下的可能性至少是特定参数值下的万倍 ” 。支持间隔取决于在替代参数下参数先前分布的规格,我们提出几种类型,允许对不同形式的外部知识进行编码。我们还表明,通过考虑一个先前的分布类别,然后计算所谓的最低支持间隔,在某种程度上可以避免事先的规格。对于某一类前一对一的间隔,该间隔带有信任间隔。我们还说明了如何根据支持概念确定未来研究的样本大小。最后,我们展示了对Bayes系数类型一误率的约束如何导致对支持间隔的束缚。对临床试验数据的应用说明了支持间隔可以如何导致直视和知情的推断。