Automatic Landmarks Correspondence Detection in Medical Images with an Application to Deformable Image Registration

Deformable Image Registration (DIR) can benefit from additional guidance using corresponding landmarks in the images. However, the benefits thereof are largely understudied, especially due to the lack of automatic detection methods for corresponding landmarks in three-dimensional (3D) medical images. In this work, we present a Deep Convolutional Neural Network (DCNN), called DCNN-Match, that learns to predict landmark correspondences in 3D images in a self-supervised manner. We explored five variants of DCNN-Match that use different loss functions and tested DCNN-Match separately as well as in combination with the open-source registration software Elastix to assess its impact on a common DIR approach. We employed lower-abdominal Computed Tomography (CT) scans from cervical cancer patients: 121 pelvic CT scan pairs containing simulated elastic transformations and 11 pairs demonstrating clinical deformations. Our results show significant improvement in DIR performance when landmark correspondences predicted by DCNN-Match were used in case of simulated as well as clinical deformations. We also observed that the spatial distribution of the automatically identified landmarks and the associated matching errors affect the extent of improvement in DIR. Finally, DCNN-Match was found to generalize well to Magnetic Resonance Imaging (MRI) scans without requiring retraining, indicating easy applicability to other datasets.