项目名称: 噪声、时滞和扩散效应作用下小RNA调控网络的动力学行为及其控制的研究
项目编号: No.11272277
项目类型: 面上项目
立项/批准年度: 2013
项目学科: 数理科学和化学
项目作者: 申建伟
作者单位: 许昌学院
项目金额: 82万元
中文摘要: 噪声、时滞和扩散效应是现实生物系统中不可避免的三个因素,他们对生物系统的动力学行为起着非常重要的作用,利用非线性动力系统理论定性的研究小RNA调控网络,揭示近年来生物学界发现的关于小RNA调控生命活动的各种机制及其动力学控制方法已成为目前该领域研究的核心问题。本项目主要研究小RNA调控的网络motif的拓扑结构和动力学行为间的关系,然后根据小RNA和mRNA的作用特点,研究小RNA调控网络中不同尺度变化导致的复杂动力学现象及其控制方法,分析噪声(包括非高斯白噪声)和时滞是如何诱导不同尺度变化所涌现出的复杂动力学现象尤其是自诱导随机共振现象。此外,我们还将研究扩散效应作用下的小RNA 网络的复杂斑图动力学行为,进一步研究噪声和时滞对相应斑图的影响以及新涌现的复杂时空动力学现象,发展随机反应扩散方程的动力学理论并利用这些理论结果来解释生命活动中各种现象发生的机制并给出控制这些现象的方法。
中文关键词: 基因调控网络;时滞;扩散效应;相干共振;
英文摘要: Noises、delay and diffusion effect are ubiquitous in biological system which play the very important role for the dynamical behaviors of the system, so studying the small RNA regulatory network by using the theory of nonlinear dynamical system and revealing the different mechanism and the dynamical control method on activity regulated by small RNA are the kernel of the problem in this field. In this project, we would investigate the relation between the topology and the dynamical behaviors of biological network regulated by small RNA, we also study the complex dynamical phenomena (especially the self-induced stochastic resonance )induced by change of different scales and the method how to control these phenomena. In addition, we would consider the diffusion effect resulted from the changes of molecular concentrations and study the behaviors of complex pattern induced by diffusion effect in the small RNA network. We would further investigate how the noises and delay affect the complex spatio-temporal dynamical behaviors,and develop the dynamical theory of stochastic reaction diffusion equation. In the meanwhile, we would plan to use the above theory and results to explain the mechanism of different phenomena in the life activity and find the method how to control these phenomena.
英文关键词: Gene regulatory network;Delay;Diffusion effect;Coherence resonance;