基于EEG-fMRI数据融合技术研究视觉工作记忆功能网络

项目名称： 基于EEG-fMRI数据融合技术研究视觉工作记忆功能网络

项目编号： No.61473062

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 其他

项目作者： 李凌

作者单位： 电子科技大学

项目金额： 80万元

中文摘要： 工作记忆是计划、决策、推理、学习、问题解决、空间加工等活动的重要环节，工作记忆的缺损会引起相应的精神/神经疾病，因此对正常人工作记忆的脑机制研究是进一步探索高级认知功能、智力活动和临床研究的基础。视觉工作记忆涉及到额叶、顶叶、枕叶和颞叶等多个脑区，形成一个复杂的神经网络。 本项目针对视觉工作记忆的动态信息处理机制问题，采用EEG-fMRI同步记录技术，发展基于MRI结构信息约束EEG皮层信号重建的方法；利用相位同步分析法建立皮层EEG 信号的动态脑功能网络、利用相关系数法构建fMRI功能网络；发展瞬时EEG功能网络和空间fMRI功能网络的时-空对称融合技术，建立EEG-fMRI功能融合网络综合图论参数与视觉工作记忆的关系模型；探讨1）视觉工作记忆中两类信息（空间和客体）的存储维持是否采用了频分多路复用技术；2）两类信息的工作记忆功能网络拓扑参数与注意容量的关系。

中文关键词： 视觉工作记忆；脑电-磁共振；相位同步；多路复用技术；功能连接

英文摘要： Working memory plays a key role in human cognition, e.g. planning, decision making, reasoning, learning, problem solving and spatial processing. Working memory disorders result in corresponding psychic/neurological diseases. Hence, the understanding of the neural mechanism of working memory in healthy individuals is fundamental for the exploration of advanced cognitive functions, intellective activities, and clinical researches. Neuroimaging studies have found a complicated neural circuit including several brain regions in the frontal, temporal, parietal and occipital lobes during the visual working memory task. This project aims to explore dynamic information processing mechanisms of visual working memory using EEG-fMRI simultaneous recording technology. A method based on structural MRI to constrain the reconstruction of EEG cortical signals will be developed. Dynamic functional networks will be constructed by cortical EEG phase synchronization and fMRI correlation coefficient, respectively. Subsequently we will explore EEG-fMRI technology by integrating spatial and temporal information and establish the relational model between EEG-fMRI functional network topological parameters and the mechanism of visual working memory. By using these technologies, we will explore 1) whether two types of information (spatial and object) storage in working memory are maintained using a frequency-division multiplexing technology; 2) the relationship between functional network topological parameters of two types of information working memory and attention capacity.

英文关键词： Visual working memory;EEG-fMRI;Phase synchronization;Multiplexing;Functional connectivity