碳酸钙-二氧化硅核壳结构光控纳米治疗体系的构建及其在抗药性肿瘤治疗中的应用

项目名称： 碳酸钙-二氧化硅核壳结构光控纳米治疗体系的构建及其在抗药性肿瘤治疗中的应用

项目编号： No.21501163

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 环境科学、安全科学

项目作者： 赵阳

作者单位： 中国科学技术大学

项目金额： 22万元

中文摘要： 在以化疗进行的临床肿瘤治疗中，肿瘤细胞和组织的抗药性已经成为危害人类健康的严重问题。目前，基于纳米颗粒介导的光热作用被发现能够特异的降低肿瘤细胞的抗药性。因此，本项目根据光热转化作用对细胞的作用原理，利用材料自身的特异性，设计了具有核壳结构药物-非晶碳酸钙@二氧化硅-光热转化剂-PEI-PEG纳米颗粒。在抗药性肿瘤治疗中，这种纳米颗粒预计将具有光热治疗、光热降低细胞抗药性、光控释药和光控降解的功能。与其他体系相比，此种多功能无机纳米载药体系的优势是在保障了高效可控治疗的同时，还具有结构简单、生物安全、合成简便和成本低廉等优点，将具备更大的临床应用潜力和价值。

中文关键词： 纳米复合材料；抗肿瘤机制；非晶碳酸钙；抗药性；光控

英文摘要： During significant advances in chemotherapy for treatment of cancer, drug resistance become the major impediment which is responsible for most of treatment failure in patients. As a new strategy, photothermal hyperthemia based on nanopartcles has been proved efficiently in drug resistant tumor therapy. Therefore, in this project, based on specific effects of photothermal function and intrinsic properties of nanomaterial, drug-amorphous calcium carbonate@silica-photothermal transfer agent-PEI-PEG nanoparticle has been designed. In the application of drug resistant tumor therapy, this nanoparticles is expected be multifunctional in aspects of photothermal therapy, reduce drug resistance, light-controlled release of drug and degradation in biological environments. Comparing with other nanosystems, this multifunctional nanoparticle is advantageous in simple structure, biosafety, simple synthesis and low cost with retention of highly controllability and efficacy. Considering the clinical feasibility of this nanosystem, it points out a new way with huge potential and great valuable to challenge drug resistance.

英文关键词： nano-composite material;mechanism of anti-tumor;amorphous calcium carbonate;drug resistant;photo-controllability