新疆肝癌脾虚湿盛证的代谢组学研究

项目名称： 新疆肝癌脾虚湿盛证的代谢组学研究

项目编号： No.81460689

项目类型： 地区科学基金项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 吕书勤

作者单位： 新疆医科大学

项目金额： 50万元

中文摘要： 肝癌是新疆特高发肿瘤之一，其发病率，死亡率逐年增高。由于新疆的地域、饮食及民族特点，使新疆肝癌患者常见病证及临床表现与湿邪为病的性质和特点相似，临床上运用健脾化湿法治疗取得了较好的疗效。本项目应用代谢组学技术和方法，从中医学脾虚湿盛导致肝癌发生的病机特点入手，选取新疆肝癌患者为研究对象，提取新疆肝癌脾虚湿盛证组及非脾虚湿盛证组、非肿瘤组脾虚湿盛证健脾化湿法治疗前后血浆、尿液,根据核磁共振波谱技术判断代谢物成分及相对含量，探寻新疆肝癌患者的特异性代谢标志物，一方面探索肝癌脾虚湿盛证的客观物质基础；另一方面揭示中医健脾化湿法治疗的分子生物学效应，为肝癌脾虚湿盛证的早期诊断、预后评估、药物干预治疗等方面提供一定依据。

中文关键词： 肝癌；脾虚湿盛证；代谢组学

英文摘要： Liver cancer is one of the Xinjiang high tumor, its incidence, the mortality rate increases year by year. Because of the Xinjiang region, restaurants and ethnic characteristics, common licence and clinical manifestations in patients with hepatocellular carcinoma in Xinjiang and the nature and characteristics of pathogenic dampness disease similar to used clinically treated with jianpi dampness and achieved good results. This project application metabolism group learn technology and method, from medical spleen virtual wet Sheng led to liver cancer occurred of disease machine features start, select Xinjiang liver cancer patients for research object, extraction Xinjiang liver cancer spleen virtual wet Sheng card group and the non-spleen virtual wet Sheng card group, and non-tumor group spleen virtual wet Sheng card health spleen of wet law treatment before and after plasma, and urine liquid, according to NMR spectrum technology judgment metabolism property ingredients and the relative content, exploring Xinjiang liver cancer patients of special heterosexual metabolism logo property, while exploration liver cancer spleen virtual wet Sheng card of objective material based One hand reveal jianpi dampness Chinese medicine in treatment of molecular biological effects, liver and spleen damp Shing permit early diagnosis, prognosis, drug treatment and other aspects provide a certain basis.

英文关键词： liver cancer;spleen-wet-sheng;Metabolomics