具有缺陷发光特性的多功能羟基磷灰石基纳米材料的构建及在骨修复中的应用研究

项目名称： 具有缺陷发光特性的多功能羟基磷灰石基纳米材料的构建及在骨修复中的应用研究

项目编号： No.51302062

项目类型： 青年科学基金项目

立项/批准年度： 2014

项目学科： 一般工业技术

项目作者： 张翠妙

作者单位： 河北大学

项目金额： 25万元

中文摘要： 介孔羟基磷灰石基纳米材料因其良好的生物相容性、生物活性及骨传导性，可作为骨修复材料应用于骨缺损疾病，该类骨修复材料作为载体负载抗生素药物还可起到控制感染、促进骨愈合的作用，因此这种多功能骨修复材料对骨科疾病的治疗及骨组织的修复和重建有重要的研究意义。然而，此类材料本身并不具备光、电、磁等功能特性，因此无法对材料的降解过程、骨修复过程及药物释放过程进行跟踪和监测。本项目拟设计合成不含稀土或过渡金属激活离子、可降解、且具有缓释功能的介孔羟基磷灰石基纳米缺陷发光材料，并通过壳聚糖的修饰进一步提高纳米材料促成骨细胞增殖的能力并改善其骨修复性能，在该材料上负载抗生素药物使其具有抗感染能力，通过荧光影像来监测和示踪该体系在体内/体外的生物降解过程、骨修复过程及药物的释放过程，获得具有骨缺损修复功能及药物输运能力的多功能纳米骨修复材料，为基于光功能化介孔羟基磷灰石的纳米生物医学功能器件的开发打下基础。

中文关键词： 纳米羟基磷灰石；介孔结构；缺陷发光；骨修复材料；药物载体

英文摘要： The mesoporous hydroxyapatite-based nanomaterials are considered to be excellent bone repair materials due to their good biocompatibility, bioactivity, and osteoconductivity, and can diliver antibiotic drug to control infection and improve bone healing. Therefore, it is of great significance to develop the multifunctional bone repair materials for the treatment of orthopedic disorders and bone reconstruction. However, the mesoporous hydroxyapatite-based nanomaterials can not monitor and track the degradation, bone repair, and drug release processes because they do not have the functional characteristics such as luminescence, electricity, magnetism, etc. In this proposal, it is expected to synthesize the defect-related luminescent, mesoporous, and biodegradable hydroxyapatite-based nanomaterials with drug release properties which do not contain rare earth and transition metal activator ions. The as-obtained nanomaterils are modified with chitosan to improve the proliferation of osteoblasts and bone repair ability, and loaded the antibiotics to enhance the anti-infection ability. The biodegradation, bone repair, and drug release processes of the nanomaterials can be monitored and tracked by the change of defect-related luminescence. The overall purpose is to obtain the multifunctional namomaterials with bone repai

英文关键词： Hydroxyapatite nanomaterials；Mesoporous structure；Defect-related luminescence；Bone repair materials；Drug carrier