基于纳米发光材料的新型荧光开关体系构建及其传感分析应用

项目名称： 基于纳米发光材料的新型荧光开关体系构建及其传感分析应用

项目编号： No.21305110

项目类型： 青年科学基金项目

立项/批准年度： 2014

项目学科： 数理科学和化学

项目作者： 金丽花

作者单位： 西北大学

项目金额： 25万元

中文摘要： 刺激响应荧光开关体系因在生物传感、智能器件、信息存储等领域的潜在应用一直是国内外科研工作者的一个研究热点。近些年来，纳米发光材料的出现为荧光开关体系的组成设计带来了巨大变革，但是迄今为止，基于纳米发光材料荧光开关体系的构筑及其应用的相关报道还比较少见，并面临许多问题，仍需进一步的探索和完善，如体系功能设计单一，在应用过程中稳定性与重现性较差等。本项目拟从研究和制备性能稳定且生物相容性好的金纳米簇发光材料和量子点发光材料出发，充分结合利用这两种材料的独特光学性质，通过选取合适的具有光、电或pH信号刺激响应功能的配体或分子，采用化学键合、包埋合成等方式，设计构建出以发光金纳米簇或量子点作为功能构筑单元，具有特定响应功能或多种响应功能于一体的智能化荧光开关体系。以期改善纳米发光材料荧光开关体系的整体性能，并进一步拓展了该体系在pH传感分析中的应用。

中文关键词： 纳米簇；硅量子点；荧光；传感器；开关体系

英文摘要： The studying of the stimuli-responsive fluorescence switch systems has attracted increasing attentions because of their potential applications in the field of biological sensing, smart devices and information storage. Recently, the emergence of the nanostructured luminescent materials has brought a dramatic change for the composition design of switch system.However，up to date，the reports about the construction or application of the nanostructured luminescent materials based fluorescence switch system are still relatively rare, and exist many problems while need to be further explored and improved, such as the poor stability and reproducibility and sole function. This project intends to fully integrate with the unique photochemical properties of the nanostructured luminescent materials, and starts from studying and preparing the gold nanoclusters and quantum dot luminescent materials with high optical stability and biocompatibility performance, through selecting the appropriate ligand or molecules with light, electricity or pH stimulate responsive functions while employing the methods of chemical bonding and embedding synthesis, to design and construct a high-quality intelligent fluorescence switch system with specific response function or many response functions into one.The new systems are expected to improve

英文关键词： Nanoclusters；Silicon nanocrystals；Fluorescence；Sensor；Switch system