伏隔核-下丘脑-杏仁核 Orexin通路调控及对胃动力和摄食影响机制研究

项目名称： 伏隔核-下丘脑-杏仁核 Orexin通路调控及对胃动力和摄食影响机制研究

项目编号： No.81470815

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 徐珞

作者单位： 青岛大学

项目金额： 73万元

中文摘要： 肥胖人口在我国迅速递增，其易引起多种并发症（如糖尿病、心脑血管疾病、高血脂等），加速衰老和死亡。食欲素（Orexin）是脑肠肽，其主要功能是促进摄食、胃肠动力、参与能量平衡调控。Orexin神经元不仅在下丘脑内部核团间构成网络联系，本研究还发现，下丘脑Orexin神经元与'享乐摄食中枢'-伏隔核和'情绪'相关中枢-杏仁核也相互连接，并参与胃动力和摄食调控。越来越多研究显示，能量平衡维持与情绪相关中枢（如杏仁核、伏隔核、隔核等）和摄食调控中枢（如下丘脑）的共激活密切相关，并引起学者们的关注。本课题意皆探讨伏隔核-下丘脑-杏仁核Orexin神经/功能通路构成、该通路在调控胃运动和摄食中的作用，以及与该通路上其它摄食调节因子对该通路信息传递的交互影响，阐明该通路与肥胖病理关系，提出该通路是中枢能量平衡调控的重要通路之一，目的是补充和完善能量平衡调控理论，为肥胖、糖尿病等的防治提供新的策略。

中文关键词： 食欲素；伏隔核-下丘脑-杏仁核通路；胃动力；肥胖；中枢调控

英文摘要： The obese people are rapidly increasing in our country. Obesity is easy to induce a variety of complications (such as diabetes, cardiovascular disease, high cholesterol) and accelerated aging and death. Orexin is a brain gut peptide which could promote feeding, gastrointestinal motility and participate in the regulation of the positive energy metabolism. Orexin neurons in hypothalamus may send their fibers not only to constitute of a network connection within the hypothalamus, the study also found that, but also to connect with 'hedonic feeding center' nucleus accumbens or 'emotional' relevant central amygdala each other, and to participate in the gastric motility and the regulation of food intake. More and more studies have shown that it is closely related to the energy balance between the emotional related central (such as the amygdala, the nucleus accumbens) and feeding related central (such as hypothalamus) co-activation. This topic is to explore the formation of orexin pathway among the nucleus accumbens, hypothalamus and amygdala, the roles of this orexin pathway in the regulation of food intake and gastric motility, as well as other factors which were regulated with food intake on interaction of the channel of information transmission. And we would like to clarify the relationship between nucleus accumbens-hypothalamus-amygdala Orexin pathway and the pathological process of obesity food intake and gastric motility disorders, to raise that the pathway of nucleus accumbens-hypothalamus-amygdala is an important pathway for the regulation of energy balance in order to supplement and improve the theory of energy balance regulation and provide new strategies and targets for prevention and treatment of obesity.

英文关键词： orexin;nucleus accumbens-hypothalamus-amygdala pathway;gastric motility;obesity;central regulation