纳米多孔金增敏的分子印迹传感器用于气体检测的研究

项目名称： 纳米多孔金增敏的分子印迹传感器用于气体检测的研究

项目编号： No.81460543

项目类型： 地区科学基金项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 李迎春

作者单位： 石河子大学

项目金额： 49万元

中文摘要： 本申请将利用纳米多孔金（NPG）和分子印迹聚合物（MIP）膜来修饰石英晶体微天平（QCM），并将其用于挥发性有机化合物的检测。研究将建立NPG在QCM上固定和MIP膜进一步修饰电极的技术，并建立所修饰传感器对目标气体肺癌标识物的特异性识别和检测的方法。前期工作已开创了通用性的传感器两步修饰技术，并完成了部分有机气体的检测，本申请的重点则放在提高传感器的灵敏性和特异性上。QCM及其阵列的应用，以及NPG和MIP的引入将实现传感器信号多重放大目的，从而降低检测限，提高专属性。本研究不仅开展了NPG用于QCM修饰的前瞻性工作，也为分子印迹技术和纳米多孔材料在传感领域的应用提供新的研究经验。课题目标是将QCM转化成用于肺癌辅助诊断的呼吸气体检测传感器。从肺癌尽早确诊可以很大程度提高病患存活率的意义出发，该产品为肺癌的大规模排查提供了全新的低成本手段，对病症的及早发现和预防有着重要意义。

中文关键词： 分子印迹聚合物；纳米多孔金；气体传感；石英微天平

英文摘要： This application is about to develop a QCM sensor system for detection of volatile organic compounds (VOC). The sensor will be firstly covered with nanoporous gold (NPG) leaf and further modified with molecularly imprinted polymeric (MIP) film. Techniques for immobilization of NPG on QCM surface, as well as modification of the NPG/QCM sensor with MIP will be studied and the method of determining VOCs existing in the breath of lung cancer patients as biomarkers will be developed. Our previous work has established the original two-step sensor coating technique and the modified sensor systmem has been applied as gas detector. In this research, sensitivity and specificity of the gas sensor are the most important factors that we attempted to improve. In order to fulfill this purpose, QCM sensor and its array system will be employed; furthermore, the involvement of NPG and MIP is expected to enhance the amplification of sensor signals multiply, therefore reducing the limit of detection and raiseing the specificity. Our work will not only open the way of combining NPG with QCM firstly, but also provide new experience concerning introduction of MIP and nanomaterials in sensing field. Since it has been proved that there exist specific biomarkers in lung cancer patients' breath, the ultimate aim of this work is to smell cancer in a simple and quick manner. This research is likely to render a new inexpensive strategy for quickly diagnosing the related cancer in wide scale, which is very meaningful for the early discovery and prevention of the disease.

英文关键词： Molecularly imprinted polymers;Nanoporous gold;Gas sensing;QCM