抗菌类药物的电化学性质及高灵敏检测方法研究

项目名称： 抗菌类药物的电化学性质及高灵敏检测方法研究

项目编号： No.21475033

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 数理科学和化学

项目作者： 俞爱民

作者单位： 湖北师范大学

项目金额： 82万元

中文摘要： 近年来，功能纳米材料在电催化分析中的应用已成为当前电化学领域的一个研究热点。鉴于石墨烯等纳米复合材料的特殊电化学性质及在发展高灵敏电化学检测器件上的潜在应用价值，本项目拟研究抗菌类药物在石墨烯纳米复合材料修饰电极上的电化学行为和电极反应机理，探索纳米复合材料对药物电化学行为的增敏作用，并在此基础上发展一系列灵敏、简单、准确的药物电化学分析方法。同时，我们还将探索一些新的电化学测试技术，如发展适体生物传感器用于非电活性药物的检测以拓展药物的电化学检测范围，并在此基础上发展可用于电化学药物测定的芯片技术，以期实现微量实际样品在此电化学芯片上的方便、快速、灵敏和高选择性测定。此项目的顺利开展不仅可进一步促进和拓展新型功能纳米材料的应用范围，发展和完善新的电化学药物测试技术，同时也可为发展下一代低成本、高灵敏的药物检测器件提供科学数据和技术平台。

中文关键词： 电分析化学；化学修饰电极；纳米复合材料；抗菌药物；传感器

英文摘要： Recently, functional nanomaterials have attracted great interests in the research field of electrochemistry for applications in electrocatalysis and electroanalysis. Graphene is a new type of nanomaterials that possess unique electrochemical properties which hold promising applications in developing high sensitive electrochemical devices. This project aims to synthesize a series of graphene based nanocomposites and study their electrochemical behaviour and their capacity to enhance the electrochemical response of antibiotics. The electrochemical behavior and the electrode reaction mechanism of some antimicrobial drugs will be studied in detail. Based on these results, a series of sensitive, simple and accurate method for the electrochemical analysis of drugs will be developed. In addition, we will also explore some new technologies such as electrochemical aptamer biosensors for the detection of non-electroactive drug molecules. Microchip technology will also be applied in order to achieve the rapid, sensitive and highly selective electrochemical measurement of drugs in trace amounts of real samples. This part of research will provide an alternative high-sensitive technique for drug measurements and greatly expand the detection range of drugs using electrochemical methods. Smooth implementation of this project will not only promote and expand the practical application of novel functional nanomaterials, it will also provide scientific data and technology platform for developing the next generation of low-cost, highly sensitive drug measurement devices.

英文关键词： Electroanalytical chemistry;Chemically modified electrodes;Nanocomposites;Antibiotics;Sensors