功能性纳米稀土荧光探针与时间分辨荧光环境分析新方法研究

项目名称： 功能性纳米稀土荧光探针与时间分辨荧光环境分析新方法研究

项目编号： No.21477011

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 化学工业

项目作者： 袁景利

作者单位： 大连理工大学

项目金额： 80万元

中文摘要： 虽然时间分辨荧光分析技术在医学临床诊断与生命科学研究中已得到了许多成功的应用，但在环境分析领域的应用及相关研究还开展的很少。本项目拟利用纳米稀土荧光探针的信号放大作用结合时间分辨荧光测定方法的无背景干扰特点，通过系列功能性纳米稀土荧光探针的研制，开展环境病原微生物的时间分辨荧光成像测定、痕量/超痕量环境有害化合物的时间分辨荧光免疫测定、环境有害离子的时间分辨荧光传感测定及环境有害化合物的时间分辨荧光免疫传感测定等研究工作，以建立一些高灵敏度的时间分辨荧光环境分析新方法，解决目前影响环境分析发展和应用的一些难题。本研究不仅对稀土荧光探针研究的发展、开拓时间分辨荧光分析技术新的研究与应用领域具有很好的理论与实际意义，其研究成果在环境监测与环境保护领域也具有很好的应用前景。

中文关键词： 稀土；荧光材料；纳米荧光探针；时间分辨荧光；环境分析

英文摘要： Time-resolved luminescence detection technique has been widely used in clinical diagnostics and life science researches, but its application in the field of environmental analysis has rarely been investigated. To solve the problems currently affecting the development and application of environmental analysis, based on the signal amplification effect of luminescent lanthanide nano-probes combined with the background-free characteristics of time-resolved luminescence method, this project intends to carry out the researches of some functional luminescent lanthanide nano-probes and their applications for time-resolved luminescence imaging detections of environmental pathogenic microorganisms, time-resolved luminescence immunoassays of trace/ultra-trace environmentally harmful compounds, time-resolved luminescence sensing detections of environmentally harmful ions and time-resolved luminescence immunosensing detections of environmentally harmful compounds, to establish a series of new methods for the highly sensitive time-resolved luminescence environmental analysis. This study not only has important theoretical and practical significance for the development of luminescent lanthanide probes to pioneer new research and application fields of time-resolved luminescence detection technique, its results have also good application prospects in the fields of environmental monitoring and environmental protection.

英文关键词： Lanthanide;Luminescent material;Luminescent nano-probe;Time-resolved luminescence;Emvironmental analysis