高灵敏高选择磁性核壳纳米SERS探针的构筑及其对农药残留的检测研究

项目名称： 高灵敏高选择磁性核壳纳米SERS探针的构筑及其对农药残留的检测研究

项目编号： No.21271136

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 数理科学和化学

项目作者： 张莉

作者单位： 宿州学院

项目金额： 75万元

中文摘要： 面对世界范围内愈来愈低的农药残留限量标准和建立食品安全实时追踪体系的需求，发展超灵敏快速准确的检测痕量农药残留的先进传感材料和检测技术具有重要的学术意义和潜在的经济价值。本项目拟将仿生免疫理念与表面增强拉曼散射（SERS）技术结合起来，运用分子组装设计和分子印记合成等手段，发展在磁芯金壳纳米颗粒表面修饰人工仿生抗体的原理和方法，组装兼有分子识别和快速富集增强能力的纳米复合颗粒SERS探针，达到对特定目标农药残留分子的高容量、高选择性识别。辅以外磁场的作用，达到对农残分子的靶向富集。并且，利用具有指纹特征、超灵敏、检测时间短等特点的SERS技术实现对痕量农残分子的快速准确检测。最后，探索通过人工仿生抗体材料层的改变实现对环境中特定农药分子高选择性检测的敏感机制。本项目的预期成果，将为环境中痕量有机污染物的超灵敏、快速准确检测提供新的思路和技术可能。

中文关键词： 纳米材料；农药残留；表面增强拉曼光谱；光催化降解；

英文摘要： The usage of pesticide has been strictly restricted, and these highly noxious chemicals have been widely-spread in the environment and accumulated in organisms. Therefore, it has important academic significance and potential economic value to develop advanced sensor materials and detection technology for ultra-sensitive, rapid, and accurate detection of trace pesticide residues. This project intends to combine the concept of bionic immune and surface-enhanced Raman scattering (SERS) technique by the use of molecular assembly design, molecular synthesis to obtain Au@Fe3O4 core-shell probes; develops the method and principles to modify artificial biomimetic antibody on the nanoparticles surface; assembles the nanocomposite particles SERS probe with both molecular recognition and rapid enrichment abilities; and realizes the high-capacity and high selectivity recognition on specific target pesticide residues molecules. Further, an external magnetic field was applied to reach the quick enrichment and separation of pesticide residues molecules. Taking the advantages of fingerprint characteristics, ultra-sensitive, short detection time of SERS technology, we can achieve fast and accurate detection of trace pesticide residues. Finally, we will explore in the sensitive mechanism of artificial biomimetic antibody materia

英文关键词： nanomaterials；pesticide residue；surface enhanced Raman spectroscopy；photocatalytic degradation；