视觉与触觉认知在低视力患者中的交互作用研究

项目名称： 视觉与触觉认知在低视力患者中的交互作用研究

项目编号： No.31200842

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 认知的脑结构与神经基础

项目作者： 刘婷婷

作者单位： 复旦大学

项目金额： 20万元

中文摘要： 视觉是人类最重要的感知觉之一，同时人类对外界的认知还依赖于不同感知觉的整合。眼病损伤视觉信号，导致大脑发生适应性改变甚至出现重塑,然而过去此类研究主要集中于全盲人群。鉴于低视力的高发病率以及视触觉交互作用对低视力功能康复的重要意义，本项目将对低视力的视觉与触觉交互作用进行研究。我们目前研究发现触觉可以激活正常视觉系统多个视觉功能区，并且功能磁共振多体素解码分析提示其激活具有刺激相关特异性。本项目拟采用功能磁共振和心理物理学方法，研究： 1、低视力触觉识别的功能改变以及触觉刺激在视觉皮层激活的功能意义；2、视觉与触觉交互作用模式的改变及其在大脑皮层的发生位置，阐明视觉损害程度和发病年龄对触觉、视觉交互作用及皮层重塑的影响。研究结果将为低视力康复提供指导意义并为人工视力提供神经基础，同时也加深对大脑重塑机制的了解，促进眼科学、影像学、认知科学等多个学科的交叉研究进展。

中文关键词： 青光眼；低视力；视觉皮层；功能磁共振；心理物理学

英文摘要： Vision, as one of the most important and critical sensation in human, also works together with other senses for recognizing the outer world and performing daily tasks. Visual impairment could lead to adaptive changes in the brain, change the model of integration and weighting between different senses, and even enhance the function of a substitutive sensory modality such as touch. Previously, people have reported that tactile perception could activate visual cortex in blind subjects and blind subjects also seem to have better tactile acuity. In the meanwhile, in normally sighted subjects, there is also interaction between visual and tactile perception and some areas in the brain that were traditionally known as exclusively visual driven can actually be activated by multiple sensory modalities. However, there is very limited research on the interaction between vision and touch in low vision. Since multisensory integration could provide potential benefit for low vision rehabilitation, especially that there might be sensory enhancement between different senses, it is important to further study the interaction between vision and touch in low vision. In order to understand the mechanism of tactile functional changes and cross-modal cortical reorganization after vision loss, we need to learn, first how touch and visi

英文关键词： glaucoma；low vision；visual cortex；fMRI；Psychophysics