介孔玻璃水泥缓释抗生素/活性维生素D治疗慢性骨髓炎合并骨延迟愈合

项目名称： 介孔玻璃水泥缓释抗生素/活性维生素D治疗慢性骨髓炎合并骨延迟愈合

项目编号： No.31271031

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 生物科学

项目作者： 苏佳灿

作者单位： 中国人民解放军第二军医大学

项目金额： 70万元

中文摘要： 本项目将研制高比表面积/孔容的介孔（2～8nm）玻璃水泥及其大孔（200～300μm）支架载药体系。将抗生素和活性维生素D装载在介孔玻璃水泥及其支架上，用于治疗慢性骨髓炎合并骨缺损及骨延迟愈合。系统地研究载药系统的生物相容性、生物活性和降解性。探索高载药量的介孔玻璃体系组成、表面性质和介孔结构等特征对成骨细胞和内皮细胞粘附、增殖和分化，以及对成骨相关基因表达的影响机制。研究活性维生素D在体内促进材料血管化和成骨的作用机制，揭示材料体内降解和新骨再生性能之间的关系，载药系统促进骨修复的机理。通过本研究，阐明材料的孔结构与性能(高比表面积/孔容)和功能(缓释、血管化和成骨等)的关系，为发展新型、有特殊功能的骨植入体提供新思路和方法，为材料临床应用提供实验依据

中文关键词： 介孔玻璃水泥；药物缓释；生物相容性；抗菌；骨组织再生

英文摘要： TThis study will develop high surface area / pore volume mesoporous (~ 8nm) glass, cement and macroporous (200 ~ 300μm) stent drug delivery system. Antibiotics and active vitamin D are loaded on the mesoporous glass cement and its bracket for the treatment of chronic osteomyelitis with bone defects and delayed bone healing. The biocompatibility of drug delivery system, biological activity and degradation will be systematically studies, which will explore the high drug loading of the mesoporous system, surface properties and structure of mesoporous characteristics of osteoblasts and endothelial cell adhesion, proliferation and differentiation, as well as the expression of osteoblast-related genes. Active vitamin D in the body can promote material vascularization and osteogenesis. This study is to reveal the relationship between the materials in vivo degradation and new bone regeneration. Through this study, the followings including the pore structure and properties of materials (high specific surface area / pore volume) and functions (sustained release, blood vessels and osteoblasts, etc.), and the relationship between the development of new special features of the bone implant will be elucidated. This will provide the experimental basis for the clinical application of this material and method

英文关键词： mesoporous glass cement；drugs sustained release；biocompatibility；antibacterial；bone regeneration