新型无机－有机杂化微球的制备及其在分离科学中的应用

项目名称： 新型无机－有机杂化微球的制备及其在分离科学中的应用

项目编号： No.21205058

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 分析化学

项目作者： 吴明火

作者单位： 南昌航空大学

项目金额： 25万元

中文摘要： 有机聚合微球在生产生活中应用非常广泛，但仍普遍存在机械强度不高、易溶涨收缩或热稳定性不好的缺点,严重影响到操作过程的重现性及微球的使用寿命。如将其应用于色谱分离填料，良好的机械性能是众多前提之一。所以，如何提高有机微球的机械强度是制备有机色谱填料亟待解决的主要问题。多面体寡聚倍半硅烷(Polyhedral oligomeric silsesquioxane, POSS)有引入具有能提高有机聚合物机械性能及热稳定性的特点，如果能将POSS试剂引入到有机微球的制备的中，就可以得到机械性能显著提高的无机-有机杂化微球。此外，热稳定性的提高也可使该填料能在较高温条件下操作，加快分离分析过程。本课题研究的目的是探索有效的方法及操作过程将POSS试剂共价引入到高分子微球中。通过系统考察及优化制备条件，最终得到尺寸合适、粒径分布窄、比表面积高、机械强度好、热稳定性优良且适用于色谱填料的杂化聚合物微球。

中文关键词： 微球；有机-无机杂化；色谱填料；样品前处理；POSS

英文摘要： Polymer microspheres have been widely used in science and industry, however there are still some common deficiencies such as lack of mechanical stability, easy in swelling or shrinkage and not enough thermal stability which leads to poor reproducibility and short service life of these microsphere materials. For using as chromatography stationary phase, the mechanical properties should be one of the first concerns since these materials have to resist the high pressure. So how to improve the mechanical property of the polymer based microspheres is an urgent and important issue to overcome. The emergence of the polyhedral oligomeric silsesquioxane (POSS) provided a very good hint to overcome these shortcomings since this kind of monomer or building blocks could greatly improve the mechanical and thermal stability of the conventional polymers as long as they were incorperated into the final product via covalent bonding or blending. And the final product consisting POSS monomers, called inorganic-silica hybrid materials. One can immagine that if the POSS was covalently incorperated into the polymer microspheres, the resulted inorganic-organic hybrid microspheres should exhit better mechanical and thermal stabity which could be more suitabe for chromatography stationary phases. So the aim of this project is to develop

英文关键词： microsphere；organic-inorganic hybrid；chromatography stationary phase；sampre pretreatment；POSS