含有芳环侧链的聚硅烷的手性转移和对映体分离

项目名称： 含有芳环侧链的聚硅烷的手性转移和对映体分离

项目编号： No.21274098

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 数理科学和化学

项目作者： 杨永刚

作者单位： 苏州大学

项目金额： 80万元

中文摘要： 本项目旨在研究含有芳环侧基的聚硅烷的手性转移性质和对映体拆分能力。首先合成含有芳环的单体，通过武慈偶联得到三个系列的聚硅烷。然后研究其手性转移性质。对于同时含有芳环和非手性侧链的聚硅烷，运用圆二色谱和量化计算研究其在溶液和聚集体状态下对手性小分子识别的机理。并将聚硅烷键合在石英片上，作为手性检测器检测小分子化合物的手性。对于同时含有芳环和手性烷基链的聚硅烷，研究单分子链和聚集体之间的手性关系，芳环侧基与硅原子之间距离以及芳环上取代基的位置对聚硅烷手性的影响。对于手性共聚物，结合圆二色谱和量化计算，研究其军官-士兵效应与高聚物结构之间的关系。最后，通过将手性聚硅烷键合在硅胶球上，研究其对映体拆分能力。该项目的成功实施有利于对聚硅烷的手性传递机理的深入理解。并且也为手性聚硅烷的实际应用奠定理论和实验基础。

中文关键词： 聚硅烷；手性；光学活性；手性转移和放大；涡流流动

英文摘要： This project aims at studying the chiral transfer and enantioseparation behaviours of the polysilanes with aromatic side chains. Firstly, monomers with aromatic rings will be synthesized. Then, three series of polysilanes will be synthesized through a Wurtz coupling reaction. Secondly, their chiral transfer behaviours will be studied. For the polysilanes with both aromatic rings and achiral alkyl side chains, their molecular recognization mechanism of chiral low-molecular-weight compounds will be studied using circular dichroism spectroscopy and quantum chemistry calculation. Then, they will be grafted on the surface of quartz and used as chirality sensors for low-molecular-weight compounds. For the polysilanes with both aromatic rings and chiral alkyl chains, the relationship between the chirality of the single chain and that of the aggregates will be studied. Moreover, the effect of the distance between the aromatic ring and silicon atom as well as the effect of the position of the subsituent groups of the aromatic rings will be also studied. For the copolymers, the sergeant-soldier effect on the structures of the polysilanes will be studied. Finally, the enantioseparation behaviours of chiral polysilanes will be studied by grafting them on the surface of silica spheres which will be used as the stationary pha

英文关键词： polysilane；chirality；optical activity；chiral transfer and amplification；vortex flow