听觉经验背景下大鼠mPFC对声音频率识别模式的研究

项目名称： 听觉经验背景下大鼠mPFC对声音频率识别模式的研究

项目编号： No.31300939

项目类型： 青年科学基金项目

立项/批准年度： 2014

项目学科： 生物科学

项目作者： 杨文伟

作者单位： 杭州电子科技大学

项目金额： 23万元

中文摘要： 大脑对声音的识别过程，对于揭示脑对感觉信息的编码规律，理解认知等脑高级功能具有重要的理论意义。其中，前额叶对声音的识别与选择性注意和记忆密切相关，对理解对于个体有重要意义的声刺激的识别非常关键，受到特别关注。本课题针对声音频率识别过程中特定听觉经验背景下大鼠内侧前额叶皮质mPFC对听感觉信息的认知编码进行研究，进一步揭示高级联合皮层参与感觉识别过程的神经活动模式和机制。主要研究内容包括：(1)应用恐惧性声音条件反射模型，建立对特定声刺激的听觉经验；(2)拓展多通道在体记录技术，研究听觉经验背景下mPFC和初级听皮层AⅠ对不同声音频率信号编码的神经元活动模式和相互关系；(3)对声音频率识别过程的双脑区编码模式进行数学建模。本项目基于中枢听觉传导通路考察mPFC的听觉识别机制并进行数学建模，有望为大脑声音识别神经机制提供理论模型，并为从生物认知角度研究工程或电子仿生信号识别提供新的途径。

中文关键词： 内侧前额叶皮层；听觉经验；声音识别；声音刺激特征；数学建模

英文摘要： The studies of sound recognition in the brain have important significance in understanding the neural coding of sensory information, as well as the perception and other higher level of brain functions. Previous studies have shown that neural coding in the prefrontal cortex during sound recognition is associated with selective attention and memory processing, which is critical for recognition of sound stimuli that have significant importance to human and animals. Special attentions have been paid to this research area. In the present proposal, we investigate the neural coding of medial prefrontal cortex (mPFC) under auditory experience during sound recognition in rats. This will help us to understand the potential mechanism of neural coding patterns in higher-order associated cortex during sensory recognition. The main works include the following. (1) Using fear sound conditioning model to establish the special auditory experience of rats to a given sound frequency stimulus; (2) Developing multichannel in vivo recording technique and implanting microelectrode arrays in mPFC and the primary auditory cortex (AI) of rats to investigate the neural coding pattern and correlation between mPFC and AI during recognizing different sound frequency stimuli under rat's various auditory experiences. (3) Based on the physiolog

英文关键词： mPFC；auditory experience；sound recognition；sound stimulus feature；computational modeling