不同生理载荷下国人腰椎间盘瞬时三维运动和形变的研究

项目名称： 不同生理载荷下国人腰椎间盘瞬时三维运动和形变的研究

项目编号： No.81472140

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 苗军

作者单位： 天津市天津医院

项目金额： 72万元

中文摘要： 椎间盘最重要功能是在运动力学上，它能转移负荷和提供脊柱一定范围的运动。掌握生理状态下椎间盘运动和形变规律对于理解椎间盘退变机制和提高脊柱疾病治疗水平有很大帮助。由于压缩负荷、剪切负荷、旋转运动、肌肉功能、韧带张力和椎间盘内外体液交换等众多复杂因素均对于调节椎间盘运动和形变有重要影响作用，通过体外实验精确模拟椎间盘生理运动几乎是不可能的。目前尚无人类生理载荷下在体椎间盘三维运动和形变数据报道。本项目拟采用双平面荧光透视系统与MRI相结合的技术来研究腰椎间盘在体运动和形变规律。让正常国人上肢不同负重（0、5、10Kg）时分别在坐、站体位下进行腰椎日常运动，摄取动态影像，导入软件系统，再与由MRI扫描获取的腰椎间盘三维模型匹配，重建在体运动，可以测算出椎间盘的旋转中心、位移、牵张、压缩、剪切等各种运动和形变参数。希望对阐述椎间盘退变发生机制和设计新型仿生人工椎间盘提供运动学数据和理论依据。

中文关键词： 椎间盘；腰；运动学；形变；脊柱外科

英文摘要： The most important function of intervertebral disc is the dynamics, it can transfer the load and provide a range of motion for the spine. Mastering the rules of the intervertebral disc movement and deformation under physiological state is helpful for understanding the mechanism of intervertebral disc degeneration and improving spinal disease treatment level. Due to the compression load,shear load, rotational movement, muscle, ligament tension and intervertebral disc fluid exchange and other many complex factors have important influence for adjusting disc movement and deformation, in vitro experiments simulating disc physiological movement is almost impossible. At present there is no human physiological loading in vivo intervertebral disc 3D motion and deformation data report. This project intends to use a combined dual fluoroscopic and MRI imaging system ( DFIS ) to study the in vivo motion and deformation of of lumbar intervertebral disc. Let the normal people take different loads (0, 5,10Kg) respectively when sitting, standing and let lumbar move like daily exercise. The dynamic image of the lumbar motion is recorded and introduced into the software to reconstruct lumbar invio motion. Many kenimatics and deformation parameters can be calculateed such as the center of rotation, displacement of intervertebral disc, stretch,compression, shear and other parameters. This kinematics data may be usefuo for the elaboration of disc degeneration mechanism and design of novel bionic artificial intervertebral disc.

英文关键词： intervertebral disc;lumbar;kenimatics;deformation;spinal surgery