流体微挤出/堆积制备组织工程支架过程形态调控机理研究

项目名称： 流体微挤出/堆积制备组织工程支架过程形态调控机理研究

项目编号： No.51475266

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 机械、仪表工业

项目作者： 陈从平

作者单位： 常州大学

项目金额： 83万元

中文摘要： 以基于流体微挤出/堆积制备组织工程支架过程为研究内容，为克服现有利用RP技术制备的支架孔隙尺寸偏大、孔隙率难以提高的缺陷，提出面向制备动态过程的多场、多参数耦合建模与形态补偿控制研究方案，并制定如下策略：1）多物理场下支架材料非线性流变学特性表征，深入研究支架材料在挤出、布施、铺展、交联过程中的流变学行为及其对支架微观孔隙结构形态的影响规律；2）构建微/纳尺度下支架材料微挤出流量预测模型，作为流量控制的基础；3）构建多物理场下面向制备过程的支架形态预测模型，为形态控制提供理论依据；4）制定面向制备过程的支架形态解耦控制策略，研究挤出流量、材料铺展交联、微管/喷头运动协同补偿控制方案，以提高支架一次成形的结构形态指标。在理论上对基于微挤出/堆积制备组织工程支架的机理和关键技术进行深入探索，在应用上又为困扰高孔隙率组织工程支架制备技术优化提供指导。因而，项目具有深远的学术意义和现实的应用前景。

中文关键词： 非牛顿流体；微挤出/堆积；组织工程；支架形态；调控机理

英文摘要： In this project, the dynamic process for preparation tissue engineering scaffold based on fluid micro-extrusion/stacking is researched. To overcome the drawbacks of scaffold prepared by RP techniques such as the over-size of pore and low porosity, it is raised a modeling and control schemes coupling multi-field, multi-parameters for the fabricating process , and the strategies are carried out as follows:1)Deeply research the material' rheological characteristic in the process of extrusion, distribution, spreading and cross linking, and the law of its influences on scaffold structure morphology; 2)Develop the extrusion- flow-prediction model of scaffold material under micro/nano dimension as the foundation of flow control; 3)Create the form-prediction model based on the fabrication process under multi-physic fields to support the theoretical basis for scaffold form control; 4)Formulate the decoupled control strategies of scaffold form, research the compensation control schemes to cooperative control the material extrusion flow, spreading and cross linking, micro-pipe/nozzle's motion in order to improve the morphology index of scaffold's prototyping for once. It is explored deeply that the mechanism and key technology of preparing the tissue engineering scaffold based on micro-extrusion/stacking in theory, at the same time, it is provided the guidance for the optimization of scaffold's preparation in practice. Therefore, the project has a profound academic meaning as well as a realistic application prospect.

英文关键词： non-Newtonian fluid;micro extrusion/accumulation;tissue engineering;scaffolds shape;regulation mechanism