LncRNA-91H作为新的结直肠癌血清标志物及其调控机制研究

项目名称： LncRNA-91H作为新的结直肠癌血清标志物及其调控机制研究

项目编号： No.81472027

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 王书奎

作者单位： 南京医科大学

项目金额： 72万元

中文摘要： 长链非编码RNA（lncRNA）可通过多种方式调控编码基因的表达，参与包括肿瘤在内的多种疾病的发生发展。胰岛素样生长因子2（IGF2）在结直肠癌（CRC）肿瘤组织中高表达，能促进肿瘤细胞的增殖、迁徙及转移。我们前期研究表明，lncRNA-91H在结直肠癌（CRC）患者癌组织及血清中均呈高表达，且与IGF2的异常高表达密切相关，但lncRNA-91H是如何调控IGF2的表达机制目前仍未明确。本项目拟在前期研究的基础上，探讨CRC中91H对IGF2表达的调控作用及其机制，以深入研究91H在CRC发生发展中的作用，并探讨血清91H 作为新的标志物在CRC早期诊断、病情分析、疗效评估和预后判断中的价值，以期为CRC的发病机制研究及临床诊断提供新的思路和新的靶标。

中文关键词： 长链非编码RNA；91H；结直肠癌；血清标志物；调控机制

英文摘要： Long non-coding RNA (lncRNA) can regulate the expression of its encoding genes by a variety of ways which is involved in the occurrence and development of many diseases including cancers. The insulin-like growth factor 2 (IGF2) which can promote proliferation, migration and metastasis of tumor cell is highly expressed in colorectal cancer (CRC). Our previous studies have shown that the expression of lncRNA-91H was high in the colorectal cancer (CRC) patients' sera and tumor tissues, which was closely related to the abnormally high expression of IGF2, but the mechanism of lncRNA-91H how to regulate the expression of IGF2 is not yet clear. On the basis of preliminary research, we intend to explore the effects and mechanism of 91H in the regulation of IGF2 expression in CRC, and investigate the role of 91H on the occurrence and development of CRC, and then explore the role of 91H in serum as a new biomarker in the early diagnosis, disease condition analysis, curative effect evaluation and prognosis of CRC, providing new ideas for the study of the pathogenesis and new targets for clinical diagnosis of CRC.

英文关键词： Long non-coding RNA;91H;colorectal cancer;serum biomarker;regulation mechanism