嘧啶羧酸类双光子吸收有机锡氧簇合物的制备及抗癌活性研究

项目名称： 嘧啶羧酸类双光子吸收有机锡氧簇合物的制备及抗癌活性研究

项目编号： No.21501001

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 数理科学和化学

项目作者： 张琼

作者单位： 安徽大学

项目金额： 20万元

中文摘要： 低成本制备高效抗癌活性新型药物具有重要的科学意义和潜在的应用价值。本项目拟设计合成具有近红外吸收的强双光子吸收有机锡氧簇合物。利用双光子吸收材料能吸收低能量光子，穿透力强，有极高的空间分辨力等优点，设计合成结构新颖的生物相容性嘧啶类小分子有机配体，根据配位选择性和立体结构特点，与有机锡氧化物或氢氧化物反应合成新型双光子嘧啶类锡氧簇合物。项目研究利用时间分辨荧光光谱、可调谐超快速激光光谱等先进技术，结合量子化学计算，探讨簇合物组分之间的能量传递过程、电子跃迁机制及双光子增强效应等光物理性质。建立具有生物活性有机锡氧簇合物分子与DNA的结合模型，利用双光子共聚焦技术研究锡氧簇合物与肿瘤细胞作用的机理。通过修饰不同靶向分子，设计针对不同肿瘤组织的靶向递药系统。研究综合性能优秀的嘧啶类双光子锡氧簇合物的抗癌活性及机理，为新型抗癌活性有机锡氧簇合物材料的设计制备、机理研究及应用提供新思想和新方法。

中文关键词： 嘧啶；双光子吸收；锡氧簇合物；抗癌活性

英文摘要： Low cost ans high efficient preparation of novel drugs with anticancer activities play a key scientific role due to their potential applications. Strong two-photon absorption organooxotin cluster in the near infrared region will be designed and synthesized in this project. Two-photon absorption materials can absorb low-energy photons with strong penetrability and highest spatial resolution. In this proposal, the novel pyrimidine ligands will be designed and synthesized based on the theoretical calculation, and then reacted with Ph3Sn(OH) and nBu6Sn2O based on coordination chemistry, thus obtaining a series novel organooxotin cluster with two-photon absorption properties. The interface transport mechanism, energy transfer mechanism, as well as the combination mode between organooxotin cluster and DNA will be discovered in detail utilizing the time-resolved fluorescent spectroscopy, tunable ultra-fast laser technology and quantum chemistry calculation. The binding model of bioactive organooxotin clusters and DNA molecules will be established as well as the mechanism of organooxotin clusters and tumor cells will be researched using two photon confocal technique.The drug delivery systems will be designed for targeting different tumor tissues by modifying directional target molecules. In order to provide new ideas and methods for designing, synthesis and application of the excellent two-photon organooxotin clusters on cancer therapy, the antitumor activity and mechanism of them will be studied.

英文关键词： Pyrimidine;Two photon absorption;Organooxotin cluster;Anticancer actiivity