多级结构石墨烯-羟基磷灰石/聚乳酸纳米复合材料制备、性能及应用研究

项目名称： 多级结构石墨烯-羟基磷灰石/聚乳酸纳米复合材料制备、性能及应用研究

项目编号： No.51463013

项目类型： 地区科学基金项目

立项/批准年度： 2015

项目学科： 一般工业技术

项目作者： 魏俊超

作者单位： 南昌大学

项目金额： 49万元

中文摘要： 纳米填料在聚合物基体中聚集、无规分布、界面相互作用薄弱已经成为限制复合材料性能的关键因素。本项目通过在石墨烯（RGO）表面负载纳米羟基磷灰石（HA），可以实现HA的均匀分散和抑制RGO片层聚集；由于RGO的片层结构存在，可以实现HA在左旋聚乳酸（PLLA）基体中局部有序排列；通过在RGO-HA表面接枝右旋聚乳酸（PDLA），可阻止纳米杂化材料在PLLA中的聚集；由于PDLA和PLLA可以形成立体复合物，因此极大的增强了纳米填料与PLLA基体的相互作用，有助于实现应力的有效转移。通过本项目的研究，可以实现纳米粒子有序排列、多尺度增强（纳米尺度HA、RGO微米尺度）、界面增强等协同作用，有望获得高性能的PLLA复合材料。通过对复合材料结晶的研究，有助于了解纳米填料、界面结晶对PLLA结晶的影响及结晶与力学性能的关系。最后，通过动物实验，有望优选出具有临床应用价值的骨组织修复材料。

中文关键词： 聚乳酸；羟基磷灰石；石墨烯；组织工程；纳米复合材料

英文摘要： The aggregation and random alignment of nanofillers in polymer matrix, and their poor phase interactions have been critical factors that limited the properties of nanocomposites. In this project, graphene-hydroxyapatite (RGO-HA) hybrid was prepared to realize the homogeneous distribution of HA and prevent aggregation of RGO sheets, in addition, the sheet structure of RGO will be helpful to realize the regular arrangement of HA in Poly(L -lactide) (PLLA) matrix. Poly(D-lactide) (PDLA) was grafted on the surface of RGO-HA, and may inhibit the aggregation of RGO-HA when filled in PLLA matrix. Due to the formation of PDLA/PLLA stereocomplex, the interfacial interaction between PLLA and RGO-HA will be greatly enhanced and may be useful to realize the effective load transfer from polymer matrix to nanofillers. So the polymer composites designed in this project combines the synergetic effects of multiscale enhancement (nanoscale HA and RGO with microscale dimensions), nanofillers regular arrangement and enhancement of interfacial interaction together, which may be helpful to obtain PLLA composites with wonderful mechanical properties. The crystallization of PLLA composites was also investigated, and may be useful to further understand not only the effect of nanofillers and interfacial crystallization on the PLLA crystallization, but also the relations between crystallization and mechanical properties. In the end, PLLA composites with potential applications in clinical for bone repair were prepared and evaluated by in vivo test.

英文关键词： polylactide;hydroxyapatite;graphene;tissue engineering;nanocomposite