大脑神经振荡动力学机制及其在癫痫疾病中的应用研究

项目名称： 大脑神经振荡动力学机制及其在癫痫疾病中的应用研究

项目编号： No.81460206

项目类型： 地区科学基金项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 何艳

作者单位： 贵州医科大学

项目金额： 47万元

中文摘要： 神经振荡指中枢神经系统神经电活动的重复性或节律活动，是大脑电活动的客观表现。神经振荡时空特性的产生和调节与大脑功能密切相关，但其在神经系统疾病的动力学机制迄今仍需要进一步探讨。课题组前期研究发现在癫痫疾病中，病灶内外脑区在癫痫发作时颅内脑电互频率耦合作用频率成分及作用强度均不同。本项目以此为切入点，选择癫痫疾病为研究对象，从神经元和神经递质、神经回路放电信息传递、大脑复杂网络性能三个层面研究大脑的频率依赖信息传递特征及潜在动力学机制。从神经元阵发放电活动中的神经元内在影响因素出发，分析阵发放电活动对神经元集群信息传递中频率响应的影响规律，并进一步研究神经网络结构与神经元振动共振行为调控的相互作用，以深入了解癫痫发作相关阵发放电活动编码与传递规律及大脑复杂网络性能的频率依赖特征，为揭示大脑神经振荡动力学机制提供新理论，并为癫痫疾病的临床辅助诊断、疗效评估和干预策略开发提供技术支持。

中文关键词： 癫痫发作；频率响应；振动共振；复杂网络；信息传递

英文摘要： Neural oscillations refer to rhythmic or repetitive neural behavior of discharges in the central nervous system, and it offers an objective description of the electrical activity in the brain.Brain functions are bound up with the generation and modulation of the spatiotemporal features in neural oscillations,while the underlying dynamical mechanism needs further research especially those that related with neurological diseases.According to the preliminary study in the research group, both the frequency component and coupling strength are different between intra and extra focus of brain regions based on cross frequency coupling analysis of intracranial EEG recordings in epilepsy. Taking it as a staring point and targeting at the epilepsy disease, this project will study the frequency dependent information transmission principle as well as the underlying dynamical mechanism of neural oscillations in three aspects divided as neuron and neurotransmitter,information transition of neural firing in circuits and complex network performance of the brain.Proceeding from the internal factors of neurons that affect neural burst firings, we will investigate the influence of neural bursts on frequency response of information transfer in neuron populations, and then we will move forward to the study of interactions between neural network structure and behavior regulation of their vibrational resonance in the network, and all this will contribute to the in-depth knowledge of neural coding and information transition principle related with epileptic seizures, which are accompanied by the frequency dependent feature of the brain network's capability.This project will provide new theory for the understanding of dynamical mechanism of neural oscillations in the brain and offer technical support for the clinical diagnosis assistance, therapeutic effect evaluation and intervention strategy invention.

英文关键词： epileptic seizure;frequency response;vibrational resonance;complex network;information transmission