心音特征与心脏血流动力的关系研究

项目名称： 心音特征与心脏血流动力的关系研究

项目编号： No.61471081

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 无线电电子学、电信技术

项目作者： 唐洪

作者单位： 大连理工大学

项目金额： 80万元

中文摘要： 心音是心脏血流动力作用于心血管而产生的机械振动。心音的定时、幅度、频率等特征会随心脏血流动力的改变而发生相应变化。心音特征与心脏血流动力之间的关系尚不明确，本项目拟建立心音特征与心脏血流动力之间较为全面、系统的关系。为此，本项目研究以下内容。（1）研究心脏的血流动力模型，模拟出心腔及大血管在各种条件下的血流动力状态。（2）研究心音的产生模型，模拟出心音对心脏血流动力的定时响应、幅度响应、频率响应，从而分析并形成心音的定时特征、幅度特征、频率特征与心脏血流动力的关系。（3）研究验证方法，设计动物实验、间接的人体实验或利用临床数据验证以上关系。（4）研究心音特征的提取方法，从采集到的体表心音中提取出相应的特征参数，用于反推心脏血流动力。本项目的完成有助于揭示心音的产生机制，有助于澄清心音特征与心脏血流动力之间的本质联系，有助于无创监测心脏血流动力，为早期筛查心脏血流动力相关疾病提供技术支持。

中文关键词： 心音信号；信号处理；特征提取；信号获取；心脏血流动力

英文摘要： Heart sounds are commonly considered as a series of mechanic vibrations of heart and vessel systems induced by heart hemodynamics. Based on this reasoning, a change in heart hemodynamics must lead to changes in heart sound timing, amplitude, and frequency. But the relations between heart sound features and hert hemodynamics are still not clear. This project tries to build systemic relations between heart sound features and heart hemodynamics. This project therefore studies the following aspects. (1) Study the heart hemodynamic model to simulate hemodynamic states for heart chambers and great vessels in normal and abnormal conditions. (2) Study the hemodynamics-based heart sound generation model to simulate timing response, amplitude response, frequency response to heart hemodynamic conditions. The relations, i.e., the responses from heart hemodynamic conditions to heart sound features, are analyzed and built up. (3) Study the validatation method, such as animal experiments, indirect human being experiments and clinical data, to validate the proposed relations. (4) Study heart sound feature extraction from heart sound recording and develop applications in noninvasive monitoring of heart hemodynaics. The achievements produced by the project is of benefit to discover the mechanism of heart sound generation, is helpful to disclose the intrinsic relations between heart sound features and heart hemodynamics, is advantageous to monitor heart hemodynamics noninvasively. The project has potential applications in detect heart hemodynamics-related disease in early stage.

英文关键词： heart sound signal;signal processing;feature extraction;signal acquisition;heart hemodynamics