面向手性化合物分离的模拟移动床异步控制基础研究

项目名称： 面向手性化合物分离的模拟移动床异步控制基础研究

项目编号： No.21276080

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 化学工业

项目作者： 李平

作者单位： 华东理工大学

项目金额： 80万元

中文摘要： 采用模拟移动床技术大规模拆分手性化合物对制药工业的发展具有重要的促进作用。与同步控制模拟移动床相比，异步控制过程可实现不同分区色谱柱数量分配和异步转换，大幅减少昂贵的手性色谱柱和固定相的数量，降低分离成本。本课题基于三种类型的手性化合物分离进行模拟移动床异步控制过程的基础研究，包括(1)对愈创木酚甘油醚、氨基乙哌啶酮和福莫特罗等手性分离筛选适宜固定相与流动相，获得高柱效低压降的手性色谱柱；(2)对色谱柱数量可变的异步控制模拟移动床，建立非线性、非平衡和多自由度的数学模型，并突破非线性动态数值求解的难点，确定异步控制的最佳分离条件，完善异步控制模拟移动床分离的理论基础；(3)基于优化设计的最佳分离区域，在VARICOL-Micro模拟移动床装置上运行异步控制过程实验分离这三类的手性化合物，修正过程数学模型，建立大规模手性分离的新方法。本项目实施将为异步控制模拟移动床的应用奠定坚实的工程基础。

中文关键词： 模拟移动床；手性分离；异步控制；色谱分离；吸附分离

英文摘要： Chiral separation by the simulated moving bed (SMB) technology has an increasing important role in promoting the development of the pharmaceutical industry. Compared with the synchronous control SMB process, the asynchronous control SMB process (called as Varcol SMB) can reduce significantly the number of chiral packed columns and the amount of expansive chiral stationary phase, so the separation cost is decreased significantly. In this project, chiral separation by Valcol SMB process is investigated theoretically and experimentally, where three types of chiral compounds are separated by, namely Guaifenesin, Aminoglutethimide, Formoterol racemic compounds. The focuses of the project are concentrated on (1)the matching stationary phase and mobile phase are selected for the sepration of each racemic compound, and the packed columns are designed optimally to have a high separation efficiency with a low flow pressure drop; (2) A nonlinear equilibrium and multi-degree of freedom mathematical model is developed, and the non-linear dynamic numerical solution is obtained to optimize the separation conditions of racemic compounds by the Varcol SMB process; (3) Based on the optimal design of separation region by simulation, three types of chiral compounds are separated experimentally by Varcol SMB process in VARICOL-Micro

英文关键词： simulated moving bed；chiral separation；asynchronous shirfting mode；chromatographic separartion；adsorption separation