新型多功能半导体纳米光热转换材料的研制及其在癌症诊疗上的应用探索

项目名称： 新型多功能半导体纳米光热转换材料的研制及其在癌症诊疗上的应用探索

项目编号： No.51472049

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 一般工业技术

项目作者： 胡俊青

作者单位： 东华大学

项目金额： 85万元

中文摘要： 半导体化合物纳米光热材料具有光热转换效率高、性能稳定、易于功能化等优势。为了进一步推进这类材料的生物应用，还需通过表面修饰、掺杂和包覆等手段，改善它们的生物兼容性和赋予其靶向性，实现诊断和治疗的联合。然而，目前半导体化合物光热材料的多功能化和靶向性研究尚处于起步阶段。本课题组成功发展了多种新型半导体化合物光热材料及其复合材料，并进行了生物应用的初步探索。 基于以上研究基础，拟开展如下工作：（1）研制多种半导体化合物纳米晶光热材料，重点研究粒径、形貌、组成和结构对其光热转换性能的影响，开发强近红外吸收、高光热转换效率和多功能（成像和载药等）的新型光热材料；（2）研究半导体化合物纳米晶光热材料的表面修饰，获得生物兼容和靶向性的光热转换材料；（3）探索半导体化合物纳米晶光热材料在小白鼠体内的毒性表现、分布转运及肿瘤诊断与治疗的效果。

中文关键词： 光热转换材料；多功能；表面修饰；诊断治疗；半导体化合物

英文摘要： Semiconductor compounds as a photothermal nanomaterial possess several advantages such as high conversion efficiency, stable performance and easy multi-function. In order to further promote the biological applications of these materials, their biocompatibility should be improved, their targeting should be endown, and their theragnosis function should be realized, by means of surface modification, doping, and coating, etc. However, the studies on their multi-function and targeting are still in their infancy. Our group has successfully developed a variety of new semiconductor compound photothermal nanomaterials and their composites, and further preliminarily explored their biological applications. Based on the above basis, the work will be carried out as follows: (1) the development of a variety of compound semiconductor nanocrystal photothermal materials, focusing on the effects of the particle size, morphology, structure and composition on their photothermal conversion properties, to develop novel photothermal materials with strong near-infrared absorption, high photothermal conversion efficiency and multi-function (bioimaging and drug loading, etc.); (2) study on their surface modification to obtain semiconductor compound photothermal nanomaterials with biocompatibility and targeting; (3) exploration of their toxicity, metabolism, targeting, and theragnosis in vivo.

英文关键词： photothermal nanomaterials;multi-function;surface modification;theragnosis;semiconductors