用于长期可植入式葡萄糖传感器材料的生物相容性改性研究

项目名称： 用于长期可植入式葡萄糖传感器材料的生物相容性改性研究

项目编号： No.31500775

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 生物科学

项目作者： 雷祎凤

作者单位： 武汉大学

项目金额： 20万元

中文摘要： 糖尿病是目前世界范围内危害人类健康的第三大疾病，动态血糖监测系统(CGMS)能极大改善糖尿病患者的生活质量。然而，到目前为止，用于CGMS的长期植入式葡萄糖传感器仍然缺乏，其关键原因是植入后传感器的生物相容性不佳而导致传感器性能下降造成的。因此，提高葡萄糖传感器表面的生物相容性，对动态血糖监测系统的发展和应用至关重要。本项目中，我们拟针对传感器的关键传感区进行材料表面修饰和改性。在外膜材料（聚氨酯，聚乙烯醇等）中掺杂修饰抗炎药物地塞米松、促血管生成肽SVVYGLR和NO释放材料，采用“主动释放药物”的概念，并结合现代纳米技术实现药物控释和缓释，通过体外、体内实验研究不同改性对传感器/组织界面的影响，减少传感器表面的异物反应、增加传感器生物相容性，从而提高葡萄糖传感器在体内的传感性能和长期使用寿命(数天至数周)。为发展长期动态血糖监测系统提供理论和技术的创新性支持。

中文关键词： 植入式葡萄糖传感器；表面与界面；表面改性；生物相容性；传感器性能

英文摘要： Diabetes mellitus becomes the third threat to public health worldwide. Continuous glucose monitoring systems (CGMS) provide real-time information of glucose changes and thus improve the life quality of diabetic patients. However, up till now, there is a tremendous lack of long-term, implanted glucose sensors for CGMS, mainly due to the poor biocompatibility of implanted sensors which further hampers the long-term sensor performance. Thus, it is critical to develop biocompatible materials for glucose sensors for future development of CGMS. Here in this work, we focus on the surface modification and biocompatibility of key sensing area of implanted glucose sensors. We modify the outer membrane (polyurethane, polyvinyl alcohol) by doping anti-inflammatory dexamethasone, angiogenic SVVYGLR peptide and NO-releasing materials, by applying the concept of “active release materials”, as well as by conjugation with nanoparticulate system which enable controlled drug releases. We aim to understanding the effects of different surface modifications onto the biocompatibility of glucose sensors from both in vitro and in vivo evaluation, thus to develop a long-term biocompatible glucose sensor with miniaturized foreign body responses and improved tissue integration, and thus to improve the in vivo glucose sensor performance for extended periods (from days to at least weeks). This project will lead to the development and application of biocompatible materials for CGMS.

英文关键词： implanted glucose sensors;surface and interface;surface modification;biocompatibility;sensor performance