酒石酸衍生物插层水滑石复合薄膜的组装及手性拆分性能研究

项目名称： 酒石酸衍生物插层水滑石复合薄膜的组装及手性拆分性能研究

项目编号： No.21476269

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 有机化学

项目作者： 焦飞鹏

作者单位： 中南大学

项目金额： 88万元

中文摘要： 本项目拟采用原位生长法及层层组装法制备酒石酸衍生物插层水滑石复合薄膜，并将其用于胺类、氨基酸类和氨基醇类等化合物的吸附手性拆分过程。层间的酒石酸衍生物依靠氢键、空间位阻等与药物对映体发生相互作用。对不同光学构型对映单体而言，这种作用力的大小存在差异，依此可实现药物对映体的手性拆分。研究吸附拆分过程中温度、吸附时间、对映体初始浓度等对吸附量及手性拆分效率的影响，确定优化的手性拆分工艺条件。对吸附后的复合薄膜进行脱附考察，以期达到再生和循环利用之目的。研究吸附过程的相关机理，考察不同温度下的平衡等温性能以及药物对映体初始浓度和操作温度对动力学的影响，并计算得出相关的热力学和动力学参数，探索揭示酒石酸衍生物与药物对映体的作用方式。本课题的完成将促进新型手性分离材料的开发，对于揭示复杂超分子体系中主客体的相互作用具有一定的理论意义，为实现此类插层LDHs薄膜材料用于外消旋体的手性拆分提供实验依据。

中文关键词： 酒石酸衍生物；水滑石；复合薄膜；插层组装；手性拆分

英文摘要： The composite films of layered double hydroxides intercalated with tartaric acid derivatives are intended to be fabricated in our project through in situ crystallization and layer-by-layer methods, and used for the enantioseparation of amines,amino acids and amino-alcohols by adsorption treatment. The intercalated tartaric acid derivatives interact with drug enantiomers through hydrogen-bonding and steric effect etc. For different optical enantiomers of a given drug, the interaction forces are different, depending on which enantioseparation of drug enantiomers can be achieved. Batch studies will be carried out to investigate the influences of various experimental parameters on the enantioseparation efficiency and adsorption capacities. These parameters that should be optimized include temperature, contact time, initial enantiomers concentration etc. The desorption behavior after adsorption treatment will be investigated for the regeneration and recycling use of the synthesized composite films. Finally, the related mechanisms involved in the adsorption process are planned to be studied. The adsorption isotherms at different temperature and the adsorption kinetics at different initial enantiomers concentrations and temperatures will be studied to calculate the thermodynamics and kinetics parameters. The mode of interactions between tartaric acid derivatives and drug enantiomers will be explored further.The completion of this project will contribute to the exploration of new enantioseparation materials. The elucidation of the enantioselective adsorption mechanism and the host-guest interaction of composite films of LDHs intercalated with tartaric acid derivatives, affords a convincing and useful experimental foundation for the application of composite films of LDHs intercalated with tartaric acid derivatives as chiral adsorbents.

英文关键词： Tartaric acid derivatives;Layered double hydroxides;Composite films;Intercalation and assembly;Enantioseparation