复方蜥蜴散不同微粒组合剂对胃粘膜损伤大鼠模型胃动力和粘膜修复作用的研究

项目名称： 复方蜥蜴散不同微粒组合剂对胃粘膜损伤大鼠模型胃动力和粘膜修复作用的研究

项目编号： No.30860360

项目类型： 地区科学基金项目

立项/批准年度： 2009

项目学科： 武器工业

项目作者： 朱西杰

作者单位： 宁夏医科大学

项目金额： 24万元

中文摘要： 胃黏膜损伤修复是消化病研究的一个重要方面，我们通过多年临床研究发现，此类疾病以气虚血瘀为主要病理基础。同时，我们还发现，机体对中药不同微粒组合剂的消化吸收作用时间不同，使药物呈现出一定的缓释效应，对胃黏膜具有极好的修复作用。本项目旨在结合我们多年应用宁夏麻蜥对胃黏膜损伤疾病修复方面的基础及临床研究，以益气养血、活血化瘀,促进黏膜修复为法，研究以宁夏密点麻蜥为主的专利技术复方蜥蜴散（蜥蜴、珍珠、牡蛎、乌梅、芍药、半枝莲、甘草、丹参、黄芪）不同微粒组合剂对无水乙醇灌胃诱发急性胃黏膜损伤和以55℃#28909;盐水、2%水杨酸、20mmol/L脱氧胆酸钠三个致萎缩因素配合饥饱失常造成CAG大鼠模型胃黏膜损伤的保护作用,通过观测胃动力、胃黏膜病理变化，并用免疫组化法研究其对大鼠胃黏膜组织细胞凋亡相关蛋白Bcl-2和Bax,胃促生长素 (ghrelin)、胃黏膜内源性保护因子前列腺素(PGE2)、一氧化氮合酶(NOS)等的影响，进而阐明复方蜥蜴散不同微粒组合对急、慢性胃黏膜损伤修复的作用机理，为胃黏膜损伤疾病的治疗和用药剂型方面提供较好的治疗思路，同时为民族医药的开发奠定基础。

中文关键词： 复方蜥蜴散；不同微粒组合剂；胃粘膜损伤；胃动力；修复

英文摘要： The gastric mucosal damage recovery was an important aspect of the digestive dieases research.We found in the clinical research that the main pathology foundation of this kind of desease was Qi dyspepsia and blood stagnation.Simultaneously, we found different digestion and absorption time with the different particle traditional Chinese medicine combination to different organism too,which makes the medicine to present certain slow release effects, has the extremely good recovery function to the gastric mucosal damage.This project was for the purpose of unifying the gastric mucosal damage desease recovery aspect foundation and the clinical research with the Ningxia dense spot Hemp Lizard in many years.Taking supplementing qi and replenishing blood, activating blood circulation to remove blood stasis, promoting the gastric mucosal recovery as the treatment rules to do the research. The protective function of the different particle combination of the compound Hemp Lizard powders(composed by Hemp Lizard, Margarita,Concha Ostreae,Fryctus Mume,Radix Paeoniae Alba,Herba Scutellariae Barbatae,Radix Glycyrrhizae,Radix Salviae Miltiorrhizae, Radix Astragali)was taken to deduce the research with the acute gastric mucosal damage caused by the absolute ethyl alcohol and of the Chronic atrophic gastritis caused by 55℃hot salt water, 2% salicylic acid, 20mmol/L sodium deoxycholate of the big mouse model.The gastric dynamic, the gastric mucosal pathological change, and influence to Bcl-2, Bax, ghrelin,PGE2, NOS with the immunohistochemical ways were observed. Then it explored the different particle combination medicinal preparation of the compound Hemp Lizard powders to the gastric mucosal damage recovery mechanism,also provided a better curing method and drug dosage forms for the recovery of the gastric mucosal damage deseases.Simultaneously,the research laid the foundation for the national medicine's development.

英文关键词： the compound Hemp Lizard powders; different particle combination; gastric mucosal damage; gastric dynamic; recovery