手性分子印迹膜的制备及其拆分过程研究

项目名称： 手性分子印迹膜的制备及其拆分过程研究

项目编号： No.21276012

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 化学工业

项目作者： 任钟旗

作者单位： 北京化工大学

项目金额： 80万元

中文摘要： 手性分子印迹膜分离技术是主要的手性药物拆分方法之一，具有选择性高、稳定性好、操作简单等优点。本申请主要以布洛芬等外消旋体的拆分为研究对象，系统探讨分子印迹手性识别机理，从分子水平上认识印迹识别过程，依据量子与统计力学理论，采用量化计算结合分子模拟的手段，设计/选择/制备合适的功能单体，以及合适的交联剂种类和数量，确定模板分子与功能单体的比例，通过分子自组装、表面修饰自由基聚合等方法，在微滤或超滤基膜表面形成一层活性分子印迹层；通过扫描电镜、傅里叶变换红外光谱等对膜形态和结构进行表征；考察所制得膜的选择拆分性能，及膜污染、膜溶胀、再生性等影响因素，进而优化分子印迹皮层的形态和结构，提高和改善膜的功能，制备具有高选择性和高通量的手性分子印迹复合膜；基于溶解－扩散机理、"门"模型等研究分子印迹膜用于手性拆分过程的传质机理，构建传质模型，最终形成一种具有自主知识产权的手性分子印迹膜制备和拆分技术。

中文关键词： 分子印迹膜；手性拆分；渗透；色氨酸；布洛芬

英文摘要： Chiral molecularly imprinted membrane(CMIM), as an effective method of enantioseparation, is a simple and stable process with maintaining high selectivity. In this project, the mechanism of molecularly imprinted chiral recognition will be clarified in detail by using racemic ibuprofen as a template molecular. Based on the theory of quantum and statistical mechanics, functional monomer can be designed, selected and prepared with molecular simulation. In addition, the species and amount of corsslinking agent as well as the ratio of template molecular and monomer can also be determined. Afterwards, molecular self-assembly and surface-modified free radical polymerization will be used to form an activity molecular imprinted layer on the surface of microfiltration and ultrafiltration membrane. The morphology and structure of membrane will be characterized by using scanning electron microscope(SEM), fourier transform infrared spectrometer(FTIR), etc. Moreover, the performance of enantioseparation, membrane fouling, membrane swelling and reproducibility of the formed membrane will be investigated for optimizing the morphology and structure of the active layer. As a result, a functional-enhanced CMIM can be obtained with high selectivity and flux. On the other hand, a mass transfer model will also be developed based on d

英文关键词： molecular imprinted membrane；chiral resolution；permeation；trytophan；ibuprofen