多色光学编码阵列磁致变色微球的制备及性能研究

项目名称： 多色光学编码阵列磁致变色微球的制备及性能研究

项目编号： No.51273084

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 一般工业技术

项目作者： 颜梅

作者单位： 济南大学

项目金额： 82万元

中文摘要： 基于磁性结构色材料的巨大应用潜力，以及多色光学编码材料在多元生物分析中显示的优势，本项目结合微流控技术，在外磁场控制下，制备粒径形貌可控、高分散性、呈阵列排布、尖晶石结构的强磁性复合纳米粒子，以其作为核材料；以微结构仿真软件理论建模指导筛选贵金属原子、上转换过渡金属原子以及共轭聚合物等多种壳体材料，并设计、组装编码阵列；采用原位生长一步法技术在磁性核上组装"无级"变色的多色编码阵列壳层，简化组装过程；通过结构和变色性能之间的响应机制研究，阐明构效关系，实现材料的形貌、尺寸可控制备以及可在大波长范围内切换材料的光谱性质，建立一种简单可调的基于核壳结构的多色光学编码阵列磁致变色材料的制备方法；根据材料对应激响应的颜色自表达功能，结合特异性功能基团，构建多色光学编码磁致变色阵列悬浮芯片，实现多色调控；用于医学诊疗、生物检测、环境监控等领域，建立高灵敏、高通量、高效率的多参数诊疗、检测方法。

中文关键词： 制备；光电化学；磁性材料；微球；生物检测

英文摘要： Based on the applied potential of the magnetochromatic materials and the advantages of multicolor-encoded materials in bioassay, we combine the micro?uidic technology to prepare magnetic nano composites materials under external magnetic field. They are used as nuclear materials with shape-tunable, good dispersibility, distributed array, and spinel-like structure. With the guide of microstructural simulation design software theory, we design and assemble encoding array to screening shell materials, including noble metal elements, upconversion transition metal atoms and conjugated polymer. By using one-step in-situ growth technology, we assemble stepless color-tunable multicolor-encoded array on the magnetic core surface to simplify the assembled process. Through the mechanism study of material structure and color-tunable performance, a relationship was developed to realize the shape and size tunable as well as change the spectrum property in a large wavelength coverage. A simple and tunable method was fabricated to prepare the core shell multicolor-encoded array magnetochromatic microparticles. The multicolor-encoded magnetochromatic array suspension chip was established according to the self-expression response of the materials combined with the specific functional group, which realized the multicolor- control.

英文关键词： prepartion；Photoelectrochemistry；magnetic materials；particles；biosensor