载18味党参丸/PLGA静电纺丝纤维膜用于皮肤组织工程

项目名称： 载18味党参丸/PLGA静电纺丝纤维膜用于皮肤组织工程

项目编号： No.51503171

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 一般工业技术

项目作者： 罗超

作者单位： 西藏大学

项目金额： 20万元

中文摘要： 本研究拟采用高压静电纺丝法将PLGA与藏药18味党参丸复合制成载药微纳米电纺纤维膜，定性或定量评价藏药新剂型对正常与非正常皮肤种子细胞的效应。通过对实验结果的分析，进一步建立实验动物模型，初步探索载藏药微纳米纤维膜用于皮肤组织工程领域。在传统藏药的基础上将药物制成微纳米尺度，更好地作用于细胞，在分子水平上发挥疗效，减少药物对正常细胞的副作用，减轻病人的痛苦。推动我国传统藏药与国际医药市场接轨，振兴民族医药经济，用民族地区特色“医药”产业经济带动民族整体环节发展。本课题在藏医理论的指导下，以传统工艺为基础，探索将藏成药18味党参丸与生物医用高分子材料结合，将其剂型改善为贴剂，有望成为皮肤组织工程支架材料。

中文关键词： 静电纺丝；18味党参丸；药物控制释放；微纳米结构；皮肤组织工程

英文摘要： This study will focus on investigating the processing parameters of the fabrication of Tibetan Medicine-18 flavor dangshen pills loaded poly (lactic-co-glycolic acid) / composite nanofibrous membrane by electrospinning, and qualitatively or quantitatively evaluating the effect of this novel Tibetan medicine formulation on normal and non-normal skin seed cells. Based on the analysis of the experimental results, an experimental animal model shall be further establish to explore the application of this Tibetan medicine formulation in skin tissue engineering, which may help to supply a new way of using Tibetan Medicine in clinical application. Fabricating the traditional Tibetan medicine into micro- / nano-scale formulations, is expected to show a better therapeutic effects on non-normal cells at the molecular level, and reduce the side effects of drugs on normal cells, which may alleviate the suffering of patients. This study can promote Chinese traditional Tibetan medicine to be in line with the international medicine market and revitalize the national medical economics, which means that it shall help the Tibetan medicine industry economy with minority regional characteristics to play an important role in driving the overall development of the whole nation. In a word, in this study, under the guidance of Tibetan medical theory and based on the traditional processing technology, we will combine the Tibetan medicine, 18 flavor dangshen pills, with biomedical polymer materials to fabricate a new formulation of Tibetan medicine, a nanofibrous patch, which is hoped to be used as the scaffold materials of skin tissue engineering.

英文关键词： electrospun;18-flavor-dangshen pills;drug controlled release;Micro-Nanostructure;skin tissue engineering