基于石墨烯的药物递送系统和光热治疗试剂的构建

项目名称： 基于石墨烯的药物递送系统和光热治疗试剂的构建

项目编号： No.21201020

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 无机化学

项目作者： 魏光成

作者单位： 滨州医学院

项目金额： 23万元

中文摘要： 我们发现在已出版的文章中，用wet-chemical方法重氮化rGO（还原氧化石墨烯）是在碱性或中性条件下并在稳定剂存在下进行的，这与教科书中阐述的重氮化反应被严格控制在酸性条件下相矛盾，否则会发生副反应并伴随副产物产生，而且稳定剂的使用也会影响重氮化。我们在预试验中发现，在没有稳定剂存在的酸性环境下，rGO能够被成功的重氮化，而且重氮化后的rGO的电子共轭度高于GO（氧化石墨烯），因此我们认为重氮化的rGO作为药物递送系统和光热治疗试剂的效果要好于GO。在已出版的文章中，基于石墨烯的药物递送系统和光热治疗试剂都是以GO为基础的，由于GO平面的电子共轭度很低以致可以忽略，这导致GO作为药物递送系统及光热治疗试剂的效果不佳。我们拟以重氮化的rGO为基础合成高效的药物递送系统和光热治疗试剂，此研究将为重氮化rGO，为基于石墨烯的药物递送系统和光热治疗试剂提供新思路和新视野。

中文关键词： 石墨烯；光热治疗；光动力治疗；药物递送系统；

英文摘要： Although the diazotization of rGO (reduced graphene oxide) using the wet-chemical method have been reported, we found that the diazotization of rGO using wet-chemical method was processed in alkaline or neutral solution which is conflicting with the knowledge of textbook which proposed that the diazotization should be processed in acid solution. Otherwise side reaction would occur and by-product would appearance and sometime the stabilizer could also affect the diazotization reaction. Under acid condition, the rGO was functionalized with the p-aminobenzoic acid which formed the diazonium ions thorough the diazotization with the wet-chemical method. In this case, surfactants or stabilizers were not applied during the diazotization.In pre-experiment, we found that the diazotization of rGO was very successful under acid condition without surfactants or stabilizers applied. And the electron conjugation degree of rGO functionalized is higher than GO (graphene oxide), so we think that the efficiency rGO functionalized as the drug delivery system and the photo-thermal therapeutic agents are higher than GO. To our best knowledge, drug (or DNA or protein) delivery systems based on graphene were all based on the graphene oxide (GO) in articles published, and the adsorption of water-insoluble drug on the graphene oxide pl

英文关键词： graphene；photothermal therapy；photodynamic therapy；drug delivery system；