纳米磁珠的导航靶向性及其增强药物溶栓的研究初探- - 纳米磁珠技术治疗急性脑梗死

项目名称： 纳米磁珠的导航靶向性及其增强药物溶栓的研究初探- - 纳米磁珠技术治疗急性脑梗死

项目编号： No.81070946

项目类型： 面上项目

立项/批准年度： 2011

项目学科： 金属学与金属工艺

项目作者： 张黎明

作者单位： 哈尔滨医科大学

项目金额： 10万元

中文摘要： 脑动脉血栓形成是脑部血管闭塞的常见原因之一，发病率正呈逐渐上升趋势，并趋于年轻化，严重危害着中老年人的身体健康。目前治疗以药物为主，疗效受到时间、出血风险、药物费用等因素的制约。运动和旋转的纳米微粒不仅具有洗刷血栓的力量，同时还具有"药物载体"的功能，而纳米微粒可以通过磁场控制其运动的方向（即导航靶向性）和洗刷力量。如果将纳米微粒与磁控技术相结合，使纳米微粒形成"纳米磁珠（Magnetic nanoparticles）"，并应用于脑动脉血栓形成的治疗，不仅能够在磁场的控制下加强药物的靶向性，而且大量磁珠运动和旋转所产生的机械力一定能够对血栓形成一种洗刷，进而达到瓦解或减小血栓的目的。因而，以此思路为理论依据，本课题组欲尝试纳米磁珠技术在血栓形成血管再通方面及联合应用纳米磁珠和tPA和/或东菱克栓酶增强药物溶栓效果的研究初探。

中文关键词： 血栓形成；纳米磁珠；磁场导航；靶向性；溶栓；

英文摘要： Cerebral artery thrombosis is a common cause of brain blood vessel occlusion, the incidence rate is gradual upward trend, and tend to be younger, and seriously endanger the health of the elderly. Current treatment with drugs mainly by the time the efficacy, bleeding risk, drug costs and other factors. Movement and rotation of the nanoparticles not only has the power of washing away blood clots, and also has a "drug carrier" function, and magnetic nanoparticles can be controlled by the direction of its movement (ie, navigation targeting) and washing power. If the nanoparticles and magnetron technology, the nano-particles form a "nano-beads (Magnetic nanoparticles)", and applied to the treatment of cerebral artery thrombosis, not only to strengthen the control of the magnetic field of drug targeting, and a large number of bead movement and rotation of the mechanical forces generated by the formation of a thrombus will be able to wash, and then to collapse or reduce the thrombus purposes. Thus, the theoretical basis of this idea, our group want to try nanobeads technology in thrombosis and recanalization in combination nanobeads and tPA and / or batroxobin thrombolytic drugs enhance the effect of Preliminary Study.

英文关键词： Thrombosis; nanobeads; magnetic navigation; targeting; thrombolytic