基于胰岛素信号转导环节的中药组分“HJJB”复方防治非酒精性脂肪肝作用机理研究

项目名称： 基于胰岛素信号转导环节的中药组分“HJJB”复方防治非酒精性脂肪肝作用机理研究

项目编号： No.81503404

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 医药、卫生

项目作者： 李红山

作者单位： 宁波大学

项目金额： 18万元

中文摘要： 在前期研究发现红景天苷（H）、绞股蓝总苷（J）、姜黄素（J）、白术多糖（B）四种有效组分的特定配比组方（简称“HJJB方”）有非常理想的防治实验性非酒精性脂肪肝（NAFLD）药效学效应及改善高胰岛素血症效应的基础上，拟分别运用高脂饮食诱导的大鼠NAFLD模型和3T3-L1脂肪细胞胰岛素抵抗模型，围绕胰岛素信号转导通路及其关联机制的关键环节，揭示HJJB方防治非酒精性脂肪肝的作用机制。并通过分析HJJB方与各单一组分对不同药理途径和靶点的干预效应和效应强度，揭示中药有效组分复方综合作用优势。为研制有复方多途径综合作用特点，作用机理清晰，物质基础明确的抗NAFLD中药复方提供坚实的基础。

中文关键词： 非酒精性脂肪性肝病；中药有效组分复方；胰岛素信号转导；作用机理

英文摘要： On the basis of certain proportion formula of four kinds of effective components with rhodiola glycosides (H), gynostemma total glycosides (J), curcumin (J) and extracted polysaccharide (B) (hereinafter referred to as HJJB compound) has ideal pharmacodynamics effect of preventing and treating experimental NAFLD and improving hyperinsulinemia which were found in the early stage of the study. NAFLD model of rats induced by single high-fat diet and 3T3-L1 fat cells insulin resistance model were used respectively to reveal mechanism of action of HJJB compound for preventing and treating nonalcoholic fatty liver disease around the key link of insulin signal transduction pathways and its associated mechanism. And the intervention effect and effect of strength of HJJB compound and each component on different pharmacological approach and target were analyzed to reveal combination advantage of effective components compound of traditional chinese medicine. To provide solid foundation of traditional chinese medicine compound of curing NAFLD which has compound multi-channel combination characteristic, clear mechanism of action and clear material base.

英文关键词： Non-alcoholic Fatty Liver Disease;Effective Component Compound of TCM;Insulin Signal Transduction;Mechanism of Action