Based on the information communicated in press releases, and finally published towards the end of 2020 by Pfizer, Moderna and AstraZeneca, we have built up a simple Bayesian model, in which the main quantity of interest plays the role of {\em vaccine efficacy} (`$\epsilon$'). The resulting Bayesian Network is processed by a Markov Chain Monte Carlo (MCMC), implemented in JAGS interfaced to R via rjags. As outcome, we get several probability density functions (pdf's) of $\epsilon$, each conditioned on the data provided by the three pharma companies. The result is rather stable against large variations of the number of people participating in the trials and it is `somehow' in good agreement with the results provided by the companies, in the sense that their values correspond to the most probable value (`mode') of the pdf's resulting from MCMC, thus reassuring us about the validity of our simple model. However we maintain that the number to be reported as `vaccine efficacy' should be the mean of the distribution, rather than the mode, as it was already very clear to Laplace about 250 years ago (its `rule of succession' follows from the simplest problem of the kind). This is particularly important in the case in which the number of successes equals the numbers of trials, as it happens with the efficacy against `severe forms' of infection, claimed by Moderna to be 100%. The implication of the various uncertainties on the predicted number of vaccinated infectees is also shown, using both MCMC and approximated formulae.
翻译:根据新闻稿所传达的信息,最后由Pfizer、Morma和AstraZeneca在2020年底出版的Pfizer、Mistra和AstraZeneca所传播的信息,我们建立了一个简单的Bayesian模型,其中主要的兴趣量与抗疫苗功效的作用有很大差异(“$\epsilon$”),由此产生的Bayesian网络由Markov Cyncle Monte Carlo(MC MC ) 处理,在JAGS通过Rjags与Rjags接口实施。作为结果,我们得到了若干概率密度函数(pdf)$epsilon$(pdf),每个值以三家制药公司提供的数据为条件。结果相当稳定,因为参加试验的人数变化很大,参与试验的人数变化很大,而且与公司提供的结果是“有良好的”。 也就是说,它们的数值与通过MCMC公司最有可能得到的值(mode)相匹配,从而让我们确信我们各种模型的有效性。我们坚持认为,数字的“延迟效能”应该以三个药厂公司提供的数据为条件。结果,结果相当稳定,其效率应该成为一个简单的分配方式,从一个简单的版本,而不是一个简单的顺序,从一个简单的顺序,从一个简单的顺序,从一个简单的顺序,从一个简单的顺序,从一个简单的顺序,从一个简单的顺序,从一个简单的是,从一个简单的顺序,从它从一个简单的顺序,从一个简单的顺序,从一个简单的是,从一个过程,从一个简单的顺序,从一个过程,从一个简单的顺序,从一个简单的顺序,从一个过程,从一个简单的顺序,从一个过程,从一个过程,从一个过程,从一个过程,从一个过程,从它从它从它从一个过程,从一个过程从一个过程从一个过程,从它从一个过程的顺序,从它从一个过程从它从它从它从一个过程从它从一个过程的顺序,从一个过程,从它从它从它从一个过程的顺序到一个过程的顺序到一个过程的顺序到一个过程从一个过程从一个过程的顺序到一个过程的走向的走向的顺序,从一个过程的走向的走向的走向的走向的顺序,从一个过程的走向的走向的走向的走向的走向的走向的走向的走向的走向的走向的走向的走向的走向的