HRI research using autonomous robots in real-world settings can produce results with the highest ecological validity of any study modality, but many difficulties limit such studies' feasibility and effectiveness. We propose Vid2Real HRI, a research framework to maximize real-world insights offered by video-based studies. The Vid2Real HRI framework was used to design an online study using first-person videos of robots as real-world encounter surrogates. The online study ($n = 385$) distinguished the within-subjects effects of four robot behavioral conditions on perceived social intelligence and human willingness to help the robot enter an exterior door. A real-world, between-subjects replication ($n = 26$) using two conditions confirmed the validity of the online study's findings and the sufficiency of the participant recruitment target ($22$) based on a power analysis of online study results. The Vid2Real HRI framework offers HRI researchers a principled way to take advantage of the efficiency of video-based study modalities while generating directly transferable knowledge of real-world HRI. Code and data from the study are provided at https://vid2real.github.io/vid2realHRI
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