The response of many governments to the COVID-19 pandemic has involved measures to control within- and between-household transmission, providing motivation to improve understanding of the absolute and relative risks in these contexts. Here, we perform exploratory, residual-based, and transmission-dynamic household analysis of the Office for National Statistics (ONS) COVID-19 Infection Survey (CIS) data from 26 April 2020 to 15 July 2021 in England. This provides evidence for: (i) temporally varying rates of introduction of infection into households broadly following the trajectory of the overall epidemic and vaccination programme; (ii) Susceptible-Infectious Transmission Probabilities (SITPs) of within-household transmission in the 15-35% range; (iii) the emergence of the Alpha and Delta variants, with the former being around 50% more infectious than wildtype and 35% less infectious than Delta within households; (iv) significantly (in the range 25-300%) more risk of bringing infection into the household for workers in patient-facing roles pre-vaccine; (v) increased risk for secondary school-age children of bringing the infection into the household when schools are open; (vi) increased risk for primary school-age children of bringing the infection into the household when schools were open since the emergence of new variants.
翻译:许多政府对COVID-19流行病的反应包括采取措施控制家庭内部和家庭之间的传染,为更好地了解这些情况下的绝对风险和相对风险提供了动力。在这里,我们对国家统计局2020年4月26日至2021年7月15日期间英格兰COVID-19感染调查(CIS)数据进行了探索性、剩余性和传播动力的家庭分析,从2020年4月26日至2021年7月15日,提供了证据,说明:(一) 大致随整个流行病和疫苗接种方案的发展轨迹而变化的家庭内传染率变化不定;(二) 家庭内传染的可能性在15-35%之间;(三) 阿尔法和三角洲变种的出现,前者的传染性比野性多50%,而后者比德尔塔家庭内感染性少35%;(四) 显著(范围为25-300 % ) 将感染带入家庭的风险增加,因为患者在接种前的角色;(五) 中等学校儿童将感染带入家庭的风险增加,因为新学校的风险增加;(六) 儿童进入新学校的风险增加。