We use autoregressive hidden Markov models and a time-frequency approach to create meaningful quantitative descriptions of behavioral characteristics of cerebellar ataxias from wearable inertial sensor data gathered during movement. Wearable sensor data is relatively easily collected and provides direct measurements of movement that can be used to develop useful behavioral biomarkers. Sensitive and specific behavioral biomarkers for neurodegenerative diseases are critical to supporting early detection, drug development efforts, and targeted treatments. We create a flexible and descriptive set of features derived from accelerometer and gyroscope data collected from wearable sensors while participants perform clinical assessment tasks, and with them estimate disease status and severity. A short period of data collection ($<$ 5 minutes) yields enough information to effectively separate patients with ataxia from healthy controls with very high accuracy, to separate ataxia from other neurodegenerative diseases such as Parkinson's disease, and to give estimates of disease severity.
翻译:我们使用自动递减隐藏的Markov模型和时间频率方法,对在流动期间收集的磨损性惯性传感器数据中小螺旋型外科动物的行为特征进行有意义的定量描述; 较容易收集的感应器数据比较容易收集,并直接测量可用于开发有用的行为生物标志的动向; 神经降解性疾病的敏感和特定行为生物标志对于支持早期发现、药物开发工作和有针对性的治疗至关重要; 我们制作了一套灵活和描述性的特征,这些特征来自在参与者执行临床评估任务时从可磨损感应收集的加速仪和陀螺仪数据,并用这些数据来估计疾病状况和严重程度。 短期的数据收集( < 5分钟)产生足够的信息,可以有效地将患有病变病的病人与非常精确的健康控制分开,将癌症与其他神经退化性疾病如帕金森氏病分开,并估计疾病的严重程度。