A sentinel network, Ob\'epine, has been designed to monitor SARS-CoV-2 viral load in wastewaters arriving at several tens of wastewater treatment plants in France as an indirect macro-epidemiological parameter. The sources of uncertainty in such monitoring system are numerous and the concentration measurements it provides are left-censored and contain numerous outliers, which biases the results of usual smoothing methods. Hence the need for an adapted pre-processing in order to evaluate the real daily amount of virus arriving to each WWTP. We propose a method based on an auto-regressive model adapted to censored data with outliers. Inference and prediction are produced via a discretised smoother which makes it a very flexible tool. This method is both validated on simulations and on real data from Ob\'epine. The resulting smoothed signal shows a good correlation with other epidemiological indicators and currently contributes to the construction of the wastewater indicators provided each week by Ob\'epine.
翻译:设计了一个监控网络Ob\'epine,以监测法国数十个废水处理厂作为间接宏观流行病学参数的SARS-COV-2病毒负载,作为间接宏观流行病学参数,这种监测系统的不确定性来源众多,其提供的浓度测量数据是左侧检查,含有许多偏向于通常平滑方法结果的离子体。因此,需要有一个经过调整的预处理方法,以便评估每个WWWTP每天收到的病毒的实际数量。我们提出了一个方法,该方法基于一种自动反向模型,适应与外部线一起审查的数据。通过离散的平滑器进行推断和预测,使其成为一个非常灵活的工具。这种方法在模拟和Ob'epine的真实数据上都得到验证。由此产生的光滑的信号表明与其他流行病学指标有着良好的相关性,目前有助于Ob\'epine每周提供的废水指标的构建。