On-the-Fly Guidance Training for Medical Image Registration

This research explores a novel approach in the realm of learning-based image registration, addressing the limitations inherent in weakly-supervised and unsupervised methods. Weakly-supervised techniques depend heavily on scarce labeled data, while unsupervised strategies rely on indirect measures of accuracy through image similarity. Notably, traditional supervised learning is not utilized due to the lack of precise deformation ground-truth in medical imaging. Our study introduces a unique training framework with On-the-Fly Guidance (OFG) to enhance existing models. This framework, during training, generates pseudo-ground truth a few steps ahead by refining the current deformation prediction with our custom optimizer. This pseudo-ground truth then serves to directly supervise the model in a supervised learning context. The process involves optimizing the predicted deformation with a limited number of steps, ensuring training efficiency and setting achievable goals for each training phase. OFG notably boosts the precision of existing image registration techniques while maintaining the speed of learning-based methods. We assessed our approach using various pseudo-ground truth generation strategies, including predictions and optimized outputs from established registration models. Our experiments spanned three benchmark datasets and three cutting-edge models, with OFG demonstrating significant and consistent enhancements, surpassing previous state-of-the-arts in the field. OFG offers an easily integrable plug-and-play solution to enhance the training effectiveness of learning-based image registration models. Code at https://github.com/miraclefactory/on-the-fly-guidance.