We present CosmoPower-JAX, a JAX-based implementation of the CosmoPower framework, which accelerates cosmological inference by building neural emulators of cosmological power spectra. We show how, using the automatic differentiation, batch evaluation and just-in-time compilation features of JAX, and running the inference pipeline on graphics processing units (GPUs), parameter estimation can be accelerated by orders of magnitude with advanced gradient-based sampling techniques. These can be used to efficiently explore high-dimensional parameter spaces, such as those needed for the analysis of next-generation cosmological surveys. We showcase the accuracy and computational efficiency of CosmoPower-JAX on two simulated Stage IV configurations. We first consider a single survey performing a cosmic shear analysis totalling 37 model parameters. We validate the contours derived with CosmoPower-JAX and a Hamiltonian Monte Carlo sampler against those derived with a nested sampler and without emulators, obtaining a speed-up factor of $\mathcal{O}(10^3)$. We then consider a combination of three Stage IV surveys, each performing a joint cosmic shear and galaxy clustering (3x2pt) analysis, for a total of 157 model parameters. Even with such a high-dimensional parameter space, CosmoPower-JAX provides converged posterior contours in 3 days, as opposed to the estimated 6 years required by standard methods. CosmoPower-JAX is fully written in Python, and we make it publicly available to help the cosmological community meet the accuracy requirements set by next-generation surveys.
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